Funder: National Institutes of Health

Due Dates: May 21, 2025 (LOI for June 20 app) | June 20, 2025 (Application) | August 8, 2025 (LOI for Sept 7 AIDS app) | September 7, 2025 (AIDS) | October 9, 2025 (Application) | January 7, 2026 (AIDS) | March 13, 2026 (Application) | May 7, 2026 (AIDS)

Funding Amounts: R61 phase: up to $500,000 direct costs (2 years); R33 phase: no budget cap (up to 3 years); total project period up to 5 years.

Summary: Supports exploratory clinical neuroscience research on substance use disorders, focusing on neurobiological mechanisms, for projects requiring budgets above the R21 limit.

Key Information: Applicants requesting ≥$500,000 direct costs in any R33 year must contact NIH at least 6 weeks before submission; preliminary data not required.