NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)
NIH's R21 grant supports early-stage, high-risk basic science studies with human participants to explore fundamental biomedical or behavioral phenomena.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health (NIH)
Due Dates: Expired (Last due date: January 8, 2025)
Funding Amounts: Up to $275,000 total direct costs over 2 years, with no more than $200,000 in any single year
Summary: Supports early-stage, high-risk basic experimental research involving human participants to explore fundamental biomedical or behavioral phenomena without specific application towards products or processes.
Key Information: This FOA requires proposed studies to be basic science clinical trials involving humans and excludes studies with specific applications toward processes or products; it has been reissued as PA-25-307 effective January 8, 2025.
Description
The NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) supports innovative, early-stage research projects that involve basic experimental studies with human participants. This funding opportunity is designed to foster novel scientific ideas, model systems, tools, agents, methodologies, or applications that could lead to breakthroughs in biomedical, behavioral, or clinical research.
This FOA specifically targets basic science clinical trials where human participants are prospectively assigned to experimental conditions to understand fundamental aspects of phenomena without a direct focus on developing specific products or processes. Studies with specific applications toward health-related products, procedures, or services should apply under other NIH clinical trial FOAs.
The program encourages exploratory and developmental projects distinct from traditional R01 grants, emphasizing novelty and potential for significant impact rather than extensive preliminary data. It is suitable for projects that may involve considerable risk but have the potential to substantially advance knowledge or methodologies.
Applicants must ensure their proposed research aligns with the scientific missions of one or more participating NIH Institutes and Centers (ICs). The FOA is not suitable for long-term projects or those aimed at incremental advances in well-established fields.
