Funder: National Institutes of Health

Due Dates: June 16, 2025 (New) | July 16, 2025 (Renewal/Resubmission/Revision) | October 16, 2025 (New) | November 16, 2025 (Renewal/Resubmission/Revision) | AIDS: January 7, 2028 | Standard NIH cycles through January 2028

Funding Amounts: Up to $275,000 direct costs over 2 years; no more than $200,000 in any single year; project period max 2 years.

Summary: Supports high-risk, early-stage basic science studies with human participants to advance understanding of fundamental phenomena, excluding application-driven research.

Key Information: Only basic experimental studies with humans that meet both the NIH clinical trial and basic research definitions are eligible; not all NIH Institutes participate—check IC-specific interests before applying.