HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
HEAL Initiative seeks research teams to study pain relief mechanisms of medical devices, addressing opioid crisis and developing safe alternatives.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: June 9, 2025 (Full application) | May 10, 2025 (Letter of Intent, optional)
Funding Amounts: Up to $1,500,000 direct costs/year for up to 5 years; budgets should match project scope and complexity.
Summary: Supports interdisciplinary teams to investigate mechanisms of pain relief by FDA-approved or -cleared medical devices, aiming to optimize non-opioid pain therapies.
Key Information: Requires at least 3 PDs/PIs from domestic institutions; clinical trial optional but only mechanistic or BESH trials are in scope.
Description
This NIH funding opportunity supports interdisciplinary research teams to uncover the mechanisms by which FDA-approved or -cleared medical devices provide pain relief. The program is part of the NIH HEAL (Helping to End Addiction Long-term) Initiative, which seeks to address the opioid crisis by advancing safe, effective, and non-addictive pain management strategies. The focus is on generating mechanistic insights that can inform and optimize device-based pain therapies, ultimately improving patient outcomes and reducing reliance on opioids.
Projects must be collaborative, leveraging diverse expertise (e.g., neuroscience, engineering, clinical research, data science) to address significant translational challenges in device-based pain management. The research should go beyond what could be achieved by individual investigators or parallel projects, requiring a team-science approach.
