HEAL Initiative: Research to Increase Implementation of Substance Use Preventive Services (R01 Clinical Trial Optional)
Funding available to research and develop effective strategies to prevent opioid misuse and use disorder, and increase the implementation of prevention services.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: June 17, 2025 | January 16, 2026
Funding Amounts: No set limit; up to $800,000 direct costs/year recommended, max 5 years; total program funding estimated at $4.65M (shared with companion NOFO).
Summary: Supports research to develop, implement, and sustain effective strategies for preventing opioid and other substance misuse, with a focus on scalable, sustainable prevention services.
Key Information: Preliminary or feasibility data required; applications must include a plan for meaningful engagement of end users; foreign organizations are not eligible to apply.
Description
This NIH funding opportunity supports investigator-initiated research to increase the implementation and sustainability of evidence-based substance use preventive services, with a particular focus on opioids. The initiative aims to address the persistent gap between research and practice by supporting projects that develop, test, and scale strategies for delivering prevention services in real-world settings. The ultimate goal is to inform and build a prevention infrastructure that can be sustained and scaled to reduce opioid and other substance misuse and use disorders.
This opportunity is part of the NIH Helping to End Addiction Long-term (HEAL) Initiative, which seeks to speed scientific solutions to the national opioid crisis. Projects must move beyond descriptive studies and focus on systematic strategies for implementation, scale-up, and sustainability of prevention services.
