Funder: National Institutes of Health

Due Dates: February 7, 2025 (New) | March 7, 2025 (Renewal/Resubmission/Revision) | June 6, 2025 (New) | July 8, 2025 (Renewal/Resubmission/Revision) | October 7, 2025 (New) | November 7, 2025 (Renewal/Resubmission/Revision) | February 6, 2026 (New) | March 6, 2026 (Renewal/Resubmission/Revision) | June 6, 2026 (New) | July 8, 2026 (Renewal/Resubmission/Revision) | July 9, 2026 (FOA expiration)

Funding Amounts: Budgets are not limited; typical project period is 5 years (UG3 phase up to 2 years, UH3 phase up to 5 years); budget should reflect project needs and generally not exceed $25,000 per subject randomized.

Summary: Supports multi-center clinical trials on neurological emergencies conducted within the NIH SIREN Network, excluding stroke trials.

Key Information: Applicants do not need to be part of the existing SIREN infrastructure; stroke trials must use NIH StrokeNet instead.