Funder: National Institutes of Health
Due Dates: September 7, 2025 | January 7, 2026 | May 7, 2026 | September 7, 2026 | January 7, 2027 (AIDS - New/Renewal/Resubmission/Revision, as allowed)
Funding Amounts: No budget cap; budgets must reflect actual project needs. Maximum project period: 5 years.
Summary: Supports multidisciplinary research to advance understanding and improve prevention, testing, and treatment of HIV/AIDS and aging, consistent with NIH Office of AIDS Research priorities.
Key Information: Clinical trials are optional; foreign and domestic organizations are eligible; applications must align with NIH HIV/AIDS research priorities.
Description
This opportunity invites applications for multidisciplinary research at the intersection of HIV/AIDS and aging. The goal is to improve understanding of the biological, clinical, and socio-behavioral aspects of aging in the context of HIV infection and its treatment, and to enhance approaches for testing, preventing, and treating HIV infection and managing related comorbidities, co-infections, and complications in diverse populations and settings. Research must align with the NIH Office of AIDS Research (OAR) priorities as outlined in NOT-OD-20-018.
Projects may include, but are not limited to:
- Studies on the mechanisms of accelerated aging in people living with HIV (PLWH)
- Research on HIV-related comorbidities, polypharmacy, and geriatric outcomes
- Interventions to improve quality of life, cognitive and physical function, and social support in older PLWH
- Leveraging existing NIH-funded cohorts, clinical networks, or data resources
- Comparative studies between older HIV-infected and non-infected populations
Applications may propose basic, translational, clinical, or behavioral research, and both clinical trial and non-clinical trial projects are allowed.
Due Dates
- September 7, 2025
- January 7, 2026
- May 7, 2026
- September 7, 2026
- January 7, 2027
All deadlines are for AIDS-related applications (new, renewal, resubmission, or revision). Applications are due by 5:00 PM local time of the applicant organization.
Funding Amount
- Budget: No specific budget limit; budgets must be well-justified and reflect the actual needs of the proposed project.
- Project Period: Up to 5 years.
- Number of Awards: Contingent on NIH appropriations and the number of meritorious applications.
Eligibility
Eligible applicants include:
- Public and private institutions of higher education
- Nonprofits (with or without 501(c)(3) status)
- For-profit organizations (including small businesses)
- State, county, city, township, and special district governments
- Native American tribal governments and organizations (federally recognized and other)
- Independent school districts
- Public housing authorities/Indian housing authorities
- Faith-based and community-based organizations
- Regional organizations
- U.S. territories and possessions
- Non-domestic (non-U.S.) entities (foreign organizations) and foreign components of U.S. organizations
Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are encouraged to apply.
Application Process
- Submission: Applications must be submitted electronically via Grants.gov using the NIH ASSIST system, Grants.gov Workspace, or an institutional system-to-system solution.
- Forms: Use the SF424 (R&R) application package and follow the NIH Research Project (R01) instructions.
- Data Management and Sharing: All applications generating scientific data must include a Data Management and Sharing Plan.
- Clinical Trials: Applications may propose clinical trials but are not required to do so. Some participating NIH Institutes have restrictions on the types of clinical trials they will support; consult the full funding announcement and contact the relevant NIH program officer.
- Large Budgets: Applicants requesting $500,000 or more in direct costs in any year must contact a Scientific/Research Contact at least 6 weeks before submission.
Additional Information
- Alignment with OAR Priorities: Applications must be consistent with NIH HIV/AIDS research priorities. Projects not aligned with these priorities will be considered non-responsive and will not be reviewed.
- Institute/Center Interests: Multiple NIH Institutes and Centers participate, each with specific interests (e.g., aging, cancer, mental health, substance use, neurology, women’s health). Applicants are strongly encouraged to contact the relevant program officer before submission.
- Use of Existing Resources: Leveraging existing NIH-funded cohorts, networks, or data is encouraged.
- Review Criteria: Applications will be evaluated for significance, innovation, approach, investigator(s), and environment, as well as for human subjects protections, inclusion plans, and budget justification.
External Links
Contact Information
| Topic | Contact | Email | Phone |
|---|
| General Grants Info | NIH Grants Information | GrantsInfo@nih.gov | 301-480-7075 |
| Application Submission | eRA Service Desk | Online Help | 301-402-7469 / 866-504-9552 |
| Grants.gov Support | Grants.gov Customer Support | support@grants.gov | 800-518-4726 |
Scientific/Research Contacts (selected):
- Ann Namkung, MPH (NIA): ann.namkung@nih.gov, 301-496-6838
- Hiroko Iida, DDS, MPH (NIDCR): hiroko.iida@nih.gov, 301-594-7404
- Elizabeth Anne Barr (ORWH): elizabeth.barr@nih.gov, 301-402-7895
- William Daley, PhD (NINDS): william.daley@nih.gov, 301-496-1431
- Vasudev R Rao, MBBS, MS (NIMH): vasudev.rao@nih.gov, 301-825-3259
- Geraldina Dominguez, PhD (NCI): domingug@mail.nih.gov, 240-781-3420
- Shimian Zou, PhD (NHLBI): shimian.zou@nih.gov, 301-827-8301
- Khoa Dinhdang Nguyen, PharmD (NIDDK): khoa.nguyen2@nih.gov, 240-743-8995
- Heiyoung Park, PhD (NIAMS): parkh1@mail.nih.gov, 301-594-5032
- Richard A Jenkins (NIDA): jenkinsri@mail.nih.gov, 301-443-6504
For additional contacts and financial/grants management contacts, see the full announcement.