Formative and Pilot Intervention Research to Optimize HIV Prevention and Care Continuum Outcomes (R34 Clinical Trial Optional)
Grant to fund research and testing of new or adapted interventions targeting HIV prevention and treatment, focusing on feasibility, acceptability, and safety.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: September 9, 2025 (AIDS applications) | January 9, 2026 (AIDS applications)
Funding Amounts: Up to $225,000 direct costs/year, max $450,000 direct costs over 3 years (R34 mechanism)
Summary: Supports formative research, intervention development, and pilot-testing of novel or adapted interventions to improve HIV prevention and care outcomes.
Key Information: Only AIDS-related applications are accepted; non-AIDS applications are not eligible under this FOA.
Description
This opportunity, offered by the National Institutes of Health (NIH) through the National Institute of Mental Health (NIMH), supports formative and pilot intervention research to optimize outcomes along the HIV prevention and care continuum. The focus is on developing, adapting, and pilot-testing interventions—behavioral, social, structural, or combination biomedical/behavioral approaches—that address feasibility, acceptability, tolerability, and safety for HIV prevention or treatment.
The R34 mechanism is intended for early-stage, pilot, or formative research, including:
- Initial development and pilot testing of innovative interventions.
- Formative implementation research to adapt evidence-based interventions.
- Development or selection of implementation strategies to improve uptake and effectiveness of HIV prevention and care.
Projects should align with NIMH Division of AIDS Research (DAR) priorities and are encouraged to address multi-level factors (individual, contextual, structural) that impact HIV outcomes, including mental health, stigma, social determinants, and disparities.
