Exploratory Studies to Investigate Mechanisms of HIV infection, Replication, Latency, and/or Pathogenesis in the Context of Substance Use Disorders (R01 Clinical Trial Not Allowed)
Funding available for studies investigating mechanisms of HIV infection, replication, latency, and pathogenesis in the context of substance use disorders.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: July 14, 2025 (Letter of Intent & Open Date) | August 14, 2025 (Application Due)
Funding Amounts: Up to $700,000 direct costs per year, max 5 years; total program funding $2,000,000; up to 3 awards expected.
Summary: Supports high-risk, high-impact exploratory studies on mechanisms of HIV infection, replication, latency, and pathogenesis in the context of substance use disorders (SUDs); clinical trials are not allowed.
Key Information: Applications must address both HIV mechanisms and SUD context; at least one aim must involve addictive substances or related pathways; non-responsive applications will be withdrawn without review.
Description
This funding opportunity supports milestone-driven, high-risk/high-impact exploratory research projects that investigate the mechanisms of HIV infection, replication, latency, and/or pathogenesis—including neuroHIV—in the context of substance use disorders (SUDs). The initiative is particularly focused on understanding how addictive substances influence HIV establishment, persistence, and disease progression, especially within the central nervous system (CNS).
Projects may develop or apply novel tools, technologies, or test innovative hypotheses to advance mechanistic understanding. The ultimate goal is to unravel the complex interactions between HIV, antiretroviral therapy (ART), and substance use, and to inform future prevention, diagnostic, or therapeutic strategies for people with SUDs.
