New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)
Encouraging innovative approaches to measure brain changes across lifespan for improved understanding of neurodevelopment and aging.
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Funder: National Institutes of Health
Due Dates: November 5, 2026 (Resubmission/revision) | February 5, 2027 (New) | March 5, 2027 (Resubmission/revision) | May 7, 2027 (Closing date)
Funding Amounts: Budgets are not limited but must reflect project needs; maximum project period is 5 years; no cost sharing required.
Summary: Supports new technologies and methods for measuring brain changes over longer timespans, paired with hypothesis-driven scientific demonstrations.
Key Information: Projects must include in vivo measurements, methods development and hypothesis-testing aims, two timepoints per participant or animal, and annual milestones.
Description
This NIH R01 opportunity supports multidisciplinary investigators developing new approaches, or applying existing approaches in novel ways, to measure brain activity, connectivity, genomics, and other brain characteristics across the lifespan. Participating institutes are NIA, NIBIB, NICHD, and NCI. The goal is to understand brain development and aging, including how early developmental parameters predict later brain health and disease.
Projects should combine a technical advance with a scientific demonstration of its utility. Approaches may involve hardware, software, biological tools, neuroimaging, single-cell measurements, connectomics, or computational models. Research may include healthy humans of any age, clinical populations, or animals. Causal interventions and parallel human–animal studies are encouraged. Including a developmental or advanced-age timepoint is encouraged to establish trajectories.
