Mentored Patient-Oriented Research Career Development Award (Parent K23 - Independent Clinical Trial Required)

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Description

This NIH funding opportunity supports the career development of individuals with a clinical doctoral degree who are committed to patient-oriented research (POR) and propose to lead an independent clinical trial. The award provides protected time (3–5 years) for mentored research and career development, aiming to foster the next generation of independent clinical investigators. The program is open to a wide range of clinical disciplines and is designed to help clinicians develop advanced research skills and experience necessary for independent research careers.

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Due Dates

• Standard NIH due dates apply, with three cycles per year for new, renewal, resubmission, and AIDS-related applications.
• Upcoming deadlines include:
  • June 12, 2024 (New)
  • July 12, 2024 (Renewal/Resubmission/Revision)
  • September 7, 2024 (AIDS)
  • October 12, 2024 (New)
  • November 12, 2024 (Renewal/Resubmission/Revision)
  • January 7, 2025 (AIDS)
  • February 12, 2025 (New)
  • March 12, 2025 (Renewal/Resubmission/Revision)
  • May 7, 2025 (AIDS)
  • ...and continuing through May 7, 2027
• All applications are due by 5:00 PM local time of the applicant organization.

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Funding Amount

• Award Duration: Up to 5 years.
• Budget: Composed of salary and other program-related expenses (e.g., tuition, research supplies, travel, statistical services).
• Salary: Provided as per the policies of the participating NIH Institute or Center (IC); see IC-specific information.
• Indirect Costs: Reimbursed at 8% of modified total direct costs.
• Number of Awards: Contingent on NIH appropriations and the number of meritorious applications.

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Eligibility

• Eligible Individuals: Must have a clinical doctoral degree (e.g., MD, DO, DDS, DMD, PharmD, clinical PhD) and have completed clinical training (specialty and, if applicable, subspecialty) by the time of award.
• Citizenship: U.S. citizens, non-citizen nationals, or permanent residents.
• Effort: Minimum 75% full-time professional effort (9 person-months) devoted to the award.
• Mentor: Applicants must identify a primary mentor with a strong track record in patient-oriented research.
• Eligible Organizations:
  • Public and private higher education institutions
  • Nonprofits (with or without 501(c)(3) status)
  • For-profit organizations (including small businesses)
  • State, local, and tribal governments
  • Other eligible entities (see full eligibility details)
• Foreign organizations are not eligible to apply. Foreign components of U.S. organizations are allowed.

Note: Current or former PDs/PIs on major NIH research or career development awards (e.g., R01, K01, K08, K23, K99/R00) are not eligible.

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Application Process

• Application Guide: Follow the NIH Career Development (K) Application Guide.
• Submission: Applications must be submitted electronically via ASSIST, institutional system-to-system solutions, or Grants.gov Workspace.
• Reference Letters: Required and must be submitted directly through eRA Commons.
• Mentor Statement: Must include a detailed plan for supervision, mentoring, and career progression.
• Institutional Commitment: The institution must provide a statement of commitment to the candidate’s development and ensure protected time for research.
• Data Management and Sharing Plan: Required for all applications.
• Consult IC-specific requirements: Not all NIH Institutes and Centers participate; see IC-specific information and contacts.

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Additional Information

• Clinical Trial Requirement: This opportunity is only for applicants proposing to lead an independent clinical trial, feasibility study, or ancillary study. Those not proposing an independent clinical trial should apply to the companion NOFO (PA-24-185).
• Mentoring Team: Multiple mentors are allowed if advantageous, but a primary mentor must be designated.
• Protected Time: Awardees must devote at least 75% effort to research and career development activities.
• Review Criteria: Emphasis on candidate’s potential, quality of the research plan, strength of mentorship, and institutional environment.
• Consultation with NIH staff is strongly encouraged before applying to ensure alignment with IC priorities.

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External Links

• NIH Funding Opportunity Announcement (PA-24-184)
• Table of IC-Specific Information, Requirements, and Staff Contacts
• NIH K23 Activity Code Information
• NIH Research Training and Career Development
• NIH Application Guide for Career Development Awards
• Grants.gov Opportunity Listing

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Contact Information

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