In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)
Investigate IMPC-generated embryo-lethal or subviable mouse strains to understand mammalian gene function for human genetic analysis.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health
Due Dates: June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision) | October 5, 2025 (New) | November 5, 2025 (Renewal/Resubmission/Revision)
Funding Amounts: Up to $499,999 direct costs per year, for up to 5 years (R01 mechanism; modular or detailed budget as appropriate)
Summary: Supports in-depth phenotyping and research using IMPC-generated knockout mouse strains with embryonic/perinatal lethality or subviability to advance understanding of mammalian gene function and human genetic variation.
Key Information: Clinical trials are not allowed; foreign and domestic applicants are eligible; Data Management and Sharing Plan required.
Description
This NIH funding opportunity supports research leveraging knockout mouse strains generated by the International Mouse Phenotyping Consortium (IMPC), particularly those exhibiting embryonic or perinatal lethality or subviability. The goal is to enable the scientific community to perform in-depth phenotyping and hypothesis-driven research on these strains, which are critical for understanding mammalian gene function and modeling human genetic variation and disease.
Projects may include:
- Detailed morphological, molecular, or functional phenotyping of embryonic, perinatal, or subviable knockout mouse strains.
- Hypothesis-driven studies on mechanisms underlying lethality, birth defects, placental dysfunction, or fertility issues.
- Research that combines non-hypothesis-driven phenotyping with mechanistic aims.
- Studies on viable heterozygotes to model human disease phenotypes.
The IMPC, including the NIH Knockout Mouse Phenotyping Program (KOMP2), is generating and characterizing knockout strains for the entire mouse genome, with a significant proportion expected to be embryonic or perinatal lethal or subviable. This FOA provides a unique opportunity to access and study these strains as they become available.
