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    Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

    Funding available for pilot research to improve access and effectiveness of treatments for drug, alcohol, and tobacco use disorders, including comorbid conditions.

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    Mental Health Research Grants 2026
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    Funder: National Institutes of Health

    Due Dates: November 16, 2026 (Resubmission/revision) | February 16, 2027 (New) | March 16, 2027 (Resubmission/revision) | October 27, 2027 (Closing date)

    Funding Amounts: Up to $450,000 in direct costs over three years, with a $225,000 annual limit

    Summary: Supports pilot health services and economic research preparing larger trials to improve substance use disorder treatment and related services.

    Key Information: Studies involving alcohol alone as the substance of use are not responsive and will not be reviewed.


    Description

    This NIH R34 planning grant, administered by the National Institute on Drug Abuse (NIDA), supports pilot and preliminary research preparing larger-scale services research effectiveness trials. Projects may test interventions, practices, or policies at provider, organizational, system, or payer levels to improve treatment access, quality, effectiveness, affordability, and utilization, including services for co-occurring medical and mental conditions.

    Support covers feasibility, acceptability, and utility assessments, trial design, protocol testing, recruitment and randomization procedures, data access, and development of materials or platforms for a subsequent R01-level trial. Both novel approaches and commonly used practices lacking sufficient evidence are relevant. Applications should identify hypothesis-driven questions within a broader conceptual model and address translation into practice. Clinical trials are optional.


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