Funder: National Institutes of Health
Due Dates: February 5, 2027 (New) | March 5, 2027 (Renewal/resubmission/revision) | June 5, 2027 (New) | July 5, 2027 (Renewal/resubmission/revision) | October 5, 2027 (New) | November 5, 2027 (Renewal/resubmission/revision) | January 7, 2028 (Closing)
Funding Amounts: No budget cap; most awards last 3–4 years, with a maximum of 5 years
Summary: Supports definitive clinical trials of post-acute mental health interventions and services to improve longer-term outcomes.
Key Information: Trials must examine intervention mechanisms as well as effectiveness in community practice settings.
Description
The National Institute of Mental Health (NIMH), part of NIH, supports R01 clinical trials evaluating therapeutic and service-delivery interventions for post-acute management of mental health conditions in youth, adults, and older adults. Trials must be sufficiently powered to definitively test effectiveness against usual care or alternative approaches. Interventions should match the stage of illness in focus and intensity, helping maintain initial treatment gains, manage residual symptoms, prevent relapse, or improve adherence and continuity of care.
The program emphasizes research-supported strategies with practical potential for sustained use. Relevant work includes continuation and maintenance treatments, care transitions, technology-assisted monitoring, adherence interventions, and stepped or sequenced care. Trials should examine target engagement, mechanisms of clinical benefit, and predictors or moderators of effectiveness. NIMH encourages scalable approaches, academic–community partnerships, hybrid effectiveness-implementation designs, and research reducing disparities in post-acute outcomes.
