Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional)

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Description

This opportunity from the National Cancer Institute (NCI) encourages revision applications (formerly "competing revisions") from currently funded NCI R01 research projects. The goal is to accelerate or expand the original research by incorporating a new technical approach or device developed through the NCI Innovative Molecular Analysis Technologies (IMAT) program. The program aims to incentivize independent validation and adoption of emerging technologies, fostering interdisciplinary collaboration and advancing cancer research.

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Due Dates

• Letter of Intent Deadlines:

  • March 5, 2025 (for April 4, 2025 application)
  • September 3, 2025 (for October 3, 2025 application)
    (Letters of intent are requested 30 days prior to the application due date.)

• Application Deadlines:

  • April 4, 2025
  • October 3, 2025
    (All applications due by 5:00 PM local time of the applicant organization.)

• No late applications will be accepted.

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Funding Amount

• Maximum Direct Costs: $150,000 per year
• Project Duration: Up to 2 years, but not to exceed the remaining period of the parent R01 grant
• Estimated Number of Awards: ~3 awards (total program funding ~$700,000 for FY2026)
• No cost sharing required.

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Eligibility

• Applicant Eligibility:

  • Only currently funded, hypothesis-driven NCI R01 research projects are eligible.
  • The parent R01 must have at least one year remaining at the time of the revision award (excluding no-cost extensions).
  • Applicants cannot request funds beyond the end date of the parent award.

• Eligible Organizations:

  • Higher education institutions (public/private)
  • Nonprofits (with or without 501(c)(3) status)
  • For-profit organizations (including small businesses)
  • State, county, city, township, and special district governments
  • Tribal governments and organizations (federally recognized and other)
  • Independent school districts, public housing authorities, regional organizations
  • Faith-based and community-based organizations
  • Non-domestic (non-U.S.) entities and components of U.S. organizations

• Technology Requirements:

  • The technology to be incorporated must have been developed with support from the NCI IMAT program.
  • The technology must not be commercially available or developed by the PI of the parent R01.
  • Applications seeking to use technologies developed by the parent R01 PI, or those that are commercially available, are not responsive.

• Clinical Trials:

  • Clinical trial proposals are optional (i.e., both clinical trial and non-clinical trial projects are eligible).

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Application Process

• Letter of Intent:

  • Not required, but strongly encouraged.
  • Should include project title, PI(s), key personnel, institutions, and the funding opportunity number/title.
  • Email to: Kelly Crotty, Ph.D. (kelly.crotty@nih.gov)

• Application Submission:

  • Use NIH ASSIST, Grants.gov Workspace, or institutional system-to-system solutions.
  • Follow the NIH How to Apply - Application Guide and the specific instructions in the NOFO.
  • Research Strategy is limited to 6 pages.
  • Clearly identify the IMAT-supported technology and its readiness for independent validation.
  • If collaborating with the technology developers, describe the nature and value of the collaboration.

• Required Registrations:

  • SAM.gov, eRA Commons, Grants.gov, and (for foreign organizations) NCAGE code.

• Review Criteria:

  • Importance of the research (significance and innovation)
  • Rigor and feasibility (approach)
  • Expertise and resources (investigator(s) and environment)
  • Additional review for human subjects, vertebrate animals, and biohazards as applicable

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Additional Information

• Non-Responsive Applications:

  • Use of commercially available technologies
  • Use of technologies not developed through NCI IMAT
  • Use of technologies developed by the parent R01 PI
  • Applications during a no-cost extension period

• Data Management and Sharing:

  • All applications must include a Data Management and Sharing Plan per NIH policy.

• Appendix:

  • Only limited appendix materials are allowed (see NIH Appendix Policy).

• Contact the scientific/research contact if you are unsure about the eligibility of your technology or project.

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External Links

• Full Funding Opportunity Announcement (NOFO)
• NCI IMAT Program Overview
• IMAT Funding Opportunities
• IMAT Funded Projects
• NIH How to Apply - Application Guide
• Grants.gov Opportunity Listing

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Contact Information

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