Funder: National Institutes of Health
Due Dates: April 4, 2025 | October 3, 2025 (Renewal/Resubmission/Revision) | Letters of Intent: March 5, 2025 | September 3, 2025 (30 days prior to application due date)
Funding Amounts: Up to $150,000 direct costs per year for up to 2 years; not to exceed the remaining duration of the parent P50 grant.
Summary: Supports revision applications from active NCI P50 centers to incorporate and validate novel NCI IMAT-supported technologies to accelerate cancer research.
Key Information: Only currently funded NCI P50 centers with at least one year left on the parent award are eligible; technology must be developed through the NCI IMAT program.
Description
This opportunity invites revision applications from currently funded National Cancer Institute (NCI) P50 specialized centers. The goal is to accelerate or expand the original research aims of the parent P50 project by integrating a new technical approach or device developed through the NCI Innovative Molecular Analysis Technologies (IMAT) program. The funding is intended to incentivize independent validation and promote the adoption of emerging technologies within the cancer research community, fostering interdisciplinary collaboration and advancing scientific discovery.
Due Dates
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Letter of Intent Deadlines:
- March 5, 2025 (for April 4, 2025 application)
- September 3, 2025 (for October 3, 2025 application)
- Letters of intent are requested 30 days prior to the application due date.
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Application Deadlines:
- April 4, 2025
- October 3, 2025
- All applications are due by 5:00 PM local time of the applicant organization.
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Review and Award Timeline:
- April 4, 2025 due date: Review July 2025 | Council October 2025 | Earliest Start December 2025
- October 3, 2025 due date: Review February 2026 | Council May 2026 | Earliest Start July 2026
Funding Amount
- Direct Costs: Up to $150,000 per year
- Project Period: Up to 2 years, not to exceed the remaining time on the parent P50 grant (excluding no-cost extensions)
- Number of Awards: Estimated 3 awards in FY2026
- Total Program Funding: Approx. $700,000 (subject to appropriations)
Eligibility
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Applicant Eligibility:
- Only currently funded NCI P50 specialized centers with at least one year remaining on the parent award (not including no-cost extensions) are eligible.
- The parent P50 grant must be active at the time of application.
- Applicants cannot request funds beyond the end date of the parent award.
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Eligible Organizations:
- Public/State and Private Institutions of Higher Education
- Nonprofits (with or without 501(c)(3) status)
- For-profit organizations (including small businesses)
- State, county, city, township, and special district governments
- Independent school districts
- Native American tribal governments and organizations
- Public housing authorities/Indian housing authorities
- Faith-based and community-based organizations
- Regional organizations
- Non-domestic (non-U.S.) entities and components of U.S. organizations
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Technology Requirements:
- The technology to be incorporated must have been developed through the NCI IMAT program.
- Technologies that are already commercially available, not developed through IMAT, or developed by a PI on the parent P50 are not eligible.
Application Process
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Submission:
- Applications must be submitted electronically via Grants.gov using NIH ASSIST or an institutional system-to-system solution.
- Follow the NIH Multi-Project Application Guide (Forms-H) and the specific instructions in the NOFO.
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Required Components:
- Overall component (including introduction, specific aims, research strategy, and resource sharing plan)
- Revision project component (detailing the IMAT-supported technology, its integration, and validation plan)
- Budget (modular unless submitted by a foreign organization)
- Human Subjects and Clinical Trials information (if applicable)
- Letters of support, biosketches, and other required attachments
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Letter of Intent:
- Not required but strongly encouraged; should include project title, PI(s), key personnel, institutions, and the NOFO number/title.
- Submit to Kelly Crotty, Ph.D. (see Contact Information below).
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Page Limits:
- Overall: 6 pages
- Revision Project: 6 pages
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Review Criteria:
- Significance, innovation, approach, investigator(s), environment, and specific impact of integrating the IMAT-supported technology.
Additional Information
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Non-Responsive Applications:
- Proposals using commercially available technologies, non-IMAT-developed technologies, or technologies developed by a PI on the parent P50 are not eligible.
- Applications seeking support during a no-cost extension period are not eligible.
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Clinical Trials:
- Applications may propose clinical trials but are not required to do so.
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Data Management and Sharing:
- All applications must include a Data Management and Sharing Plan in accordance with NIH policy.
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Foreign Organizations:
- Eligible to apply; must follow NIH policies for foreign institutions.
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Multiple Applications:
- Applicant organizations may submit more than one application if each is scientifically distinct.
External Links
Contact Information