NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)
NIH StrokeNet seeks clinical trials and biomarker studies for stroke treatment, recovery, and prevention, offering infrastructure support for selected projects.
Funder: National Institutes of Health
Due Dates: June 20, 2025 (New) | July 18, 2025 (Renewal/Resubmission/Revision) | October 20, 2025 (New) | November 19, 2025 (Renewal/Resubmission/Revision) | February 19, 2026 (New) | March 16, 2026 (Renewal/Resubmission/Revision) | June 18, 2026 (New) | July 20, 2026 (Renewal/Resubmission/Revision) | October 19, 2026 (New) | November 19, 2026 (Renewal/Resubmission/Revision)
Funding Amounts: No set budget limit; UG3 phase up to 1 year, UH3 phase up to 4 years (up to 6 years with strong justification); budgets must reflect actual project needs.
Summary: Supports multi-site clinical trials, biomarker validation, and ancillary studies for stroke treatment, recovery, and prevention, conducted within the NIH StrokeNet infrastructure.
Key Information: All applications must use NIH StrokeNet infrastructure; prior NINDS approval required before submission; foreign organizations may not apply, but foreign components are allowed.
Description
This opportunity from the National Institutes of Health (NIH), specifically the National Institute of Neurological Disorders and Stroke (NINDS), supports multi-site exploratory and confirmatory clinical trials, biomarker or outcome measure validation studies, and ancillary studies related to stroke treatment, recovery, and prevention. All funded projects are conducted within the NIH StrokeNet, a national network designed to accelerate and standardize stroke research.
The program uses a bi-phasic, milestone-driven cooperative agreement (UG3/UH3). The initial UG3 phase (up to 1 year) supports planning and start-up activities, with possible transition to a UH3 implementation phase (up to 4 years, or up to 6 years with strong justification) upon meeting defined milestones.
Projects may include:
- Multi-center clinical trials of promising interventions (including pragmatic and adaptive designs)
- Biomarker or outcome validation studies preparatory to clinical trials
- Ancillary studies adding scientific aims to active StrokeNet studies
Applicants do not need to be part of the existing StrokeNet infrastructure but must plan to use it for their proposed research.
