New Approaches for Measuring Brain Changes Across Longer Timespans (R21 Clinical Trial Optional)
Supporting innovative and novel research to measure brain changes over longer periods, impacting neurodevelopment, aging, and disease risk in both humans and animals across all ages.
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Funder: National Institutes of Health
Due Dates: November 16, 2026 (Resubmission/revision) | February 16, 2027 (New applications) | March 16, 2027 (Resubmission/revision) | May 7, 2027 (Closing date)
Funding Amounts: Up to $275,000 in direct costs over two years, with no more than $200,000 in any year
Summary: Supports innovative tools and methods for measuring brain changes within individuals across longer stretches of the lifespan.
Key Information: Projects must include in vivo measurements at two or more timepoints per participant or animal and annual milestones.
Description
This NIH R21 exploratory/developmental program supports multidisciplinary research developing highly novel approaches—or innovative applications of existing approaches—to measure brain activity, connectivity, genomics, and other anatomical or functional changes over longer timespans. Participating institutes are the National Institute on Aging (NIA), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and National Cancer Institute (NCI).
Projects may develop hardware, software, biological tools, or other experimental advances that integrate repeated brain measurements from the same individual. Research may involve healthy people of any age, clinical groups with cognitive, motor, or affective regulation challenges, or animals. The goal is to connect earlier brain development with later health and disease. Preliminary data and hypothesis-testing aims are not required, although both may be included. Clinical trials are optional.
