NIST Single-Cell Force Spectroscopy through AFM for Mechanics and Kinetics of Cell-Materials and Cell-Cell Adhesive Interaction
NIST seeks research to develop AFM-based single-cell force spectroscopy for measuring cell adhesion to materials and other cells.
This grant is no longer accepting proposals
NRC Research Associateship Programs has archived this opportunity.
Funder: NRC Research Associateship Programs
Due Dates: February 1, 2025 | May 1, 2025 | August 1, 2025 | November 1, 2025
Funding Amounts: $82,764 stipend plus $3,000 travel allowance; typical appointment duration 2 years.
Summary: Postdoctoral fellowship at NIST to develop atomic force microscopy (AFM)-based single-cell force spectroscopy for quantitative measurement of cell adhesion mechanics and kinetics.
Key Information: Open to U.S. citizens with a doctoral degree; requires contacting a NIST research adviser prior to application; NIST participates in February and August review cycles.
Description
This fellowship opportunity is offered by the Material Measurement Laboratory at the National Institute of Standards and Technology (NIST) through the NRC Research Associateship Programs. The research focuses on developing and applying single-cell force spectroscopy (SCFS) using atomic force microscopy (AFM) to quantitatively measure adhesive interactions at the single-cell level. The goal is to understand the mechanics and kinetics of cell adhesion to implantable materials, extracellular matrix (ECM), and other cells, as well as initial adhesion of pathogenic bacteria to host surfaces.
The SCFS technique provides precise measurements of adhesive force, energy, and kinetics, which are critical for advancing standards and measurement methods related to laboratory-grown cells and tissues. This research supports the development of reliable biomaterials and antibacterial surfaces, with applications in tissue engineering and implantable medical devices.
Key research systems include:
- Cell adhesion to extracellular matrix components, relevant to physiological and pathological processes.
- Initial adhesion mechanisms of pathogenic bacteria to host surfaces, important for developing defense strategies.
References
- Chiang MYM, et al. Biomaterials 34: 9754-9762, 2013
- Taubenberger AV, et al. Tissue Engineering Part B: 20, 2014
