Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels
NIH plans to fund expert panels to manually review and define the clinical importance of genes and variants for the ClinGen resource, improving understanding and diagnosis of genetic conditions.
Funder: National Institutes of Health
Due Dates: May 25, 2026 (estimated, forecasted)
Funding Amounts: Estimated total funding: $880,000 | Expected number of awards: 4
Summary: Supports the establishment and continuation of expert panels to curate and define the clinical relevance of genes and variants as part of the NIH Clinical Genome Resource (ClinGen).
Key Information: Forecasted opportunity; details may change—refer to the program page for updates.
Description
This upcoming opportunity, led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) alongside several other NIH Institutes and Centers, is intended to fund Genomic Curation Expert Panels. These panels will manually curate, review, and define the clinical relevance of genes and genetic variants as part of the NIH-established Clinical Genome Resource (ClinGen). The goal is to address the challenge of variants of unknown significance (VUS) in genomic medicine by systematically determining the clinical significance of genes and variants linked to diseases prioritized by participating NIH Institutes and Centers.
Funded panels must utilize NHGRI ClinGen and NCBI ClinVar procedures, tools, and informatics infrastructure. Their work will contribute to a centralized, authoritative, and public resource aggregating and sharing expert-curated data about genetic conditions and causative variants.
