[Orthopaedic Research and Education Foundation](https://www.oref.org)

August 11, 2025 (Letter of Intent) | October 14, 2025 (Full application)

$100,000 total award; typically one-year project duration.

Supports early-stage investigators researching innovative enabling technologies to advance musculoskeletal health care and improve clinical outcomes.

--- ## Description This grant honors John W. Brown, former CEO of Stryker, and is dedicated to supporting early-stage investigators working on enabling technologies in musculoskeletal health care. The program seeks investigator-initiated research proposals, particularly those focused on innovative technological solutions expected to deliver clinical benefits and improve patient outcomes. Multidisciplinary research is encouraged, and the grant is designed to foster the development of new technologies that can advance the field of orthopaedics. --- ## Due Dates - August 11, 2025: Letter of Intent (LOI) deadline - October 14, 2025: Full application deadline --- ## Funding Amount - Total award of $100,000. - Funding is typically for a one-year project period. --- ## Eligibility - **Early-Stage Investigator:** Must have completed terminal research degree or post-graduate clinical training within the past 10 years. - **No Prior Major Grant as PI:** Must not have previously competed successfully for an NIH R01 or equivalent (e.g., VA, DOD, NSF) as Principal Investigator. - **Institutional Requirements:** Applications accepted from domestic non-profit, public, and private institutions of higher education (hospitals, medical schools, universities, colleges). - **Orthopaedic Surgeon Requirement:** An orthopaedic surgeon must be involved as PI, co-PI, co-I, or MPI. - **Project Requirements:** Research must address enabling technologies in musculoskeletal care, with clinical relevance clearly stated. - **Application Limits:** A PI may submit only one LOI per grant cycle and may only apply in one category per cycle (restriction does not apply to Co-PI status). --- ## Application Process - **Letter of Intent:** Submit LOI by August 11, 2025. - **Full Application:** Invited applicants submit full proposals by October 14, 2025. - **Submission Portal:** Applications are submitted via proposalCENTRAL. Applicants must create an account if they do not already have one. - **Additional Materials:** Refer to the [grant details page](https://www.oref.org/for-researchers/funding-opportunities/grant-details/oref-john-w-brown-early-stage-investigator-enabling-technologies-in-musculoskeletal-care-research-grant) and the Request for Applications (RFA) on proposalCENTRAL for full requirements. --- ## Additional Information - Preference is given to projects studying innovative technologies with anticipated clinical benefits. - Multidisciplinary projects are strongly encouraged. - Clinical relevance must be clearly articulated in the abstract, specific aims, and study design. --- ## External Links - [Grant Details & Application Instructions](https://www.oref.org/for-researchers/funding-opportunities/grant-details/oref-john-w-brown-early-stage-investigator-enabling-technologies-in-musculoskeletal-care-research-grant) - [OREF Main Website](https://www.oref.org) - [OREF Grant FAQs](https://www.oref.org/about-oref/resources/faqs) - [OREF Contact Page](https://www.oref.org/about-oref/contact-us) --- ## Contact Information | Type | Details | |--------------|----------------------------------------------| | Email | info@oref.org | | Phone | (847) 698-9980 | | Mailing Addr | 9400 W. Higgins Road, Suite 215, Rosemont, IL 60018-4975 | | Web Contact | [Contact OREF](https://www.oref.org/about-oref/contact-us) |

OREF/John W. Brown Early-Stage Investigator Enabling Technologies in Musculoskeletal Care Research Grant

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