[Orthopaedic Research and Education Foundation](https://www.oref.org)

August 2026 (Letter of Intent) | October 2026 (Full application)

Up to $92,500 total per award; typically for one year.

Supports research on multimodal, opioid-sparing perioperative pain management and regional anesthesia techniques for orthopaedic patients.

Requires a CRNA as PI or co-PI; see eligibility for details.

--- ## Description This grant supports investigator-initiated research in perioperative musculoskeletal pain management, with a focus on opioid-sparing, non-narcotic, and multimodal pain control strategies. Projects may also investigate the safest and most effective regional anesthesia techniques for patients undergoing orthopaedic surgeries, including assessment of patient-reported outcomes and functional assessments. The overall goal is to improve pain management practices in the perioperative setting and advance clinical care for orthopaedic patients. --- ## Due Dates - August 2026: Letter of Intent deadline (anticipated/projected) - October 2026: Full application deadline (anticipated/projected) *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Maximum award: $92,500 (typically for a one-year project) - Funding is intended for direct research costs associated with eligible projects. --- ## Eligibility - A Certified Registered Nurse Anesthetist (CRNA) must serve as Principal Investigator (PI) or co-PI. - If a PhD is PI, a CRNA must be co-PI. - If an MD is co-PI, they must have a valid US medical license. - The CRNA must meet requirements for Continuous Professional Certification by the National Board of Certification and Recertification for Nurse Anesthetists (NBCRNA). - A PhD PI or co-PI must hold a faculty appointment. - Applicants may submit only one Letter of Intent (LOI) per grant cycle as PI. - Clinical relevance must be clearly demonstrated in the application. --- ## Application Process - Submit a Letter of Intent (LOI) by the anticipated August 2026 deadline. - If invited, submit a full application by the anticipated October 2026 deadline. - Applications are managed via [proposalCENTRAL](https://proposalcentral.com/). - Review the [grant details page](https://www.oref.org/for-researchers/funding-opportunities/grant-details/pain-management) and the RFA on proposalCENTRAL for complete instructions and eligibility requirements. --- ## Additional Information - Only one application per PI per cycle is allowed for this category; this does not restrict co-PI applications or applications to other categories. - Projects must generate results with practical application to orthopaedic clinical practice. - OREF encourages submission of basic, translational, and clinical studies. --- ## External Links - [Grant Details & Application Instructions](https://www.oref.org/for-researchers/funding-opportunities/grant-details/pain-management) - [OREF Funding Opportunities Overview](https://www.oref.org/for-researchers/funding-opportunities) - [OREF Grant FAQs](https://www.oref.org/about-oref/resources/faqs) - [OREF Grant Forms](https://www.oref.org/about-oref/resources/grant-forms) --- ## Contact Information | Purpose | Contact | |----------------------|----------------------------------------------| | General Inquiries | [info@oref.org](mailto:info@oref.org) | | Grants Team | [grants@oref.org](mailto:grants@oref.org) | | Phone | (847) 698-9980 | | Online Contact Form | [Contact OREF](https://www.oref.org/about-oref/contact-us) | ---

OREF Multimodal Musculoskeletal Perioperative Pain Management Grant in collaboration with the American Association of Nurse Anesthetists (AANA) Foundation

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