Funder: Patient-Centered Outcomes Research Institute

Due Dates (Anticipated): September 2026 (Letter of Intent) | December 2026 (Deferral request deadline) | January 2027 (Full application)

Funding Amounts: Up to $120M total; individual awards: Category 1 ≤$5M, Category 2 >$5M–$12M, Category 3 (PCORnet) ≤$12M direct costs; max duration 5 years.

Summary: Funds high-impact, patient-centered comparative effectiveness research (CER), with emphasis on menopause, maternal sleep, and dementia-related mental health, but open to any investigator-initiated CER topic.

Key Information: Individuals may not apply; foreign organizations must justify U.S. relevance; meaningful patient/stakeholder engagement required.