Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 3 2025
Funds large, patient-centered clinical effectiveness research on menopause, maternal sleep health, and ADRD mental health, emphasizing rigorous, real-world studies with strong patient and stakeholder engagement.
Funder: Patient-Centered Outcomes Research Institute
Due Dates (Anticipated): September 2026 (Letter of Intent) | January 2027 (Full Application)
Funding Amounts: Up to $120 million total; individual projects: Category 1 ≤ $5M direct costs, Category 2/3 up to $12M direct costs; up to 5 years/project.
Summary: Supports high-impact, patient-centered comparative clinical effectiveness research, with emphasis on menopause, maternal sleep health, and ADRD mental health.
Key Information: This is a forecasted opportunity—dates are projected based on annual cycles.
Description
This Patient-Centered Outcomes Research Institute (PCORI) funding opportunity supports large, pragmatic, patient-centered comparative clinical effectiveness research (CER) projects. The program encourages rigorous studies—preferably individual or cluster randomized controlled trials, but well-designed natural experiments and observational studies are also eligible—that address clinically meaningful questions and outcomes important to patients and stakeholders. Research should be designed for real-world impact and facilitate the widespread uptake of findings, including through hybrid effectiveness-implementation approaches.
For this cycle, PCORI highlights three Special Areas of Emphasis (SAEs):
- Treatments and strategies for menopausal symptoms
- Interventions to promote maternal sleep health during pregnancy and postpartum
- Strategies to address mental and behavioral health challenges in individuals with Alzheimer’s Disease and Related Dementias (ADRD) and their care partners
Projects outside these areas are also welcome, as long as they align with PCORI's broad mission of patient-centered CER. All applications must include meaningful patient and stakeholder engagement throughout the research process, following PCORI’s Foundational Expectations for Partnerships in Research.
