Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement -- Cycle 2 2025
Forecasted
Supports large, patient-centered randomized trials comparing widely used healthcare interventions, requiring stakeholder engagement, rigorous design, and a two-phase structure with feasibility and full-scale study stages.
This grant is no longer accepting proposals
Patient-Centered Outcomes Research Institute has archived this opportunity.
Funder: Patient-Centered Outcomes Research Institute
Due Dates (Anticipated): May 2026 (Letter of Intent) | September 2026 (Full application)
Funding Amounts: Up to $22 million direct costs per project (feasibility phase: $2M, full-scale study: $20M) over 6.5 years; total funds available up to $120M.
Summary: Supports large, patient-centered comparative effectiveness randomized trials using a two-phase structure with required stakeholder engagement and rigorous trial design.
Key Information: This is a forecasted opportunity; all deadlines are projected and subject to change.
Description
This funding opportunity supports large-scale, patient-centered comparative clinical effectiveness research (CER) projects that address critical decisions faced by patients, families, caregivers, clinicians, and the healthcare community where evidence is lacking. Projects must propose significant individual-level or cluster randomized controlled trials comparing interventions already in widespread use or with robust evidence of efficacy. The award follows a two-phase approach: an initial feasibility phase for study refinement, infrastructure setup, and stakeholder engagement, followed by a full-scale study phase contingent on meeting specific milestones. Meaningful patient and stakeholder engagement is required throughout, guided by PCORI’s Foundational Expectations for Partnerships in Research. Shared trial leadership with an independent data coordinating center (DCC) is mandatory to oversee analytical, statistical, and data management aspects. The program welcomes investigator-initiated, patient-centered CER across all health topics, with encouragement to align with PCORI’s evolving Research Project Agenda Topic Themes.
