Funder: Patient-Centered Outcomes Research Institute (PCORI)
Due Dates: May 13, 2025 (LOI) | September 3, 2025 (Full Application, by invitation)
Funding Amounts: Up to $22 million direct costs per project (Feasibility phase: $2M, up to 18 months; Full-scale phase: $20M, up to 5 years; total project period up to 6.5 years)
Summary: Supports large, high-impact randomized controlled trials in patient-centered comparative effectiveness research, with a required feasibility phase and strong stakeholder engagement.
Key Information: Requires dual leadership (Clinical and Data Coordinating Centers); only one large RCT per award; minimum direct cost request is $12M; patient care costs may be requested with strong justification.