Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
NIMH funds pilot trials to assess effectiveness of interventions for managing mental health post-acute stage, informing future larger-scale trials.
Funder: National Institutes of Health
Due Dates: June 5, 2025 (New) | July 5, 2025 (Renewal/Resubmission/Revision) | October 5, 2025 (New) | November 5, 2025 (Renewal/Resubmission/Revision) | February 5, 2026 (New) | March 5, 2026 (Renewal/Resubmission/Revision) | June 5, 2026 (New) | July 5, 2026 (Renewal/Resubmission/Revision) | October 5, 2026 (New) | November 5, 2026 (Renewal/Resubmission/Revision) | February 5, 2027 (New) | March 5, 2027 (Renewal/Resubmission/Revision) | June 5, 2027 (New) | July 5, 2027 (Renewal/Resubmission/Revision) | October 5, 2027 (New) | November 5, 2027 (Renewal/Resubmission/Revision)
Funding Amounts: Up to $750,000 direct costs over 3 years; no more than $250,000 direct costs in any single year.
Summary: Supports pilot clinical trials to evaluate the preliminary effectiveness, feasibility, and safety of post-acute interventions and services for mental health conditions, informing future larger-scale effectiveness studies.
Key Information: Clinical trial required; only pilot post-acute intervention studies are eligible; foreign organizations may apply.
Description
This opportunity, offered by the National Institute of Mental Health (NIMH) at NIH, funds pilot effectiveness trials to evaluate therapeutic and service delivery interventions for the post-acute management of mental health conditions. The focus is on interventions matched to the stage of illness, aiming to consolidate and maintain gains from initial treatment, manage residual symptoms, prevent relapse, and promote adherence and appropriate service use.
The pilot phase is intended to:
- Assess feasibility, tolerability, acceptability, safety, and potential effectiveness of the intervention.
- Determine whether the intervention engages the hypothesized target(s)/mechanism(s) underlying its effects.
- Generate preliminary data needed for a future, fully powered effectiveness trial.
Projects must be clinical trials with prospective data collection and assignment to intervention conditions. The program encourages research that addresses disparities in post-acute care outcomes for underserved groups and supports a deployment-focused model that considers end-user and practice setting perspectives.
