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    Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials (R34 Clinical Trial Optional)

    Supports pilot and feasibility studies to prepare substance use and HIV intervention and services research trials, including prevention, treatment, and recovery research.

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    Funder: National Institutes of Health

    Due Dates: February 16, 2027 (New) | March 16, 2027 (Resubmission/Revision) | June 16, 2027 (New) | July 16, 2027 (Resubmission/Revision) | October 16, 2027 (New) | November 16, 2027 (Resubmission/Revision) | February 16, 2028 (New) | March 16, 2028 (Resubmission/Revision) | June 16, 2028 (New) | July 16, 2028 (Resubmission/Revision) | October 16, 2028 (New) | November 16, 2028 (Resubmission/Revision) | February 16, 2029 (New) | March 16, 2029 (Resubmission/Revision) | June 16, 2029 (New) | July 16, 2029 (Resubmission/Revision; final closing)

    Funding Amounts: Up to $450,000 in direct costs over three years; maximum $225,000 in any year

    Summary: Supports pilot and feasibility research preparing future substance use prevention, treatment, recovery services, and HIV-related trials.

    Key Information: Meaningful end-user involvement is required; preliminary data are not required.


    Description

    This NIH R34 planning grant supports rigorous pilot and feasibility studies that inform future efficacy, effectiveness, or services research trials. Participating components include the National Institute on Drug Abuse (NIDA) and Office of AIDS Research, with potential co-funding from the Office of Disease Prevention. Studies should generate preliminary evidence for larger trials rather than provide definitive tests of effectiveness. Clinical trials are optional.

    Research areas include substance use prevention interventions, treatment and recovery services, and HIV research at the intersection of substance use and HIV risk, prevention, and care. Interests include intervention development and adaptation, feasibility and acceptability, implementation strategies, care engagement and retention, workforce capacity, and services addressing co-occurring medical or mental health conditions. Projects should explain how their findings will inform a future trial.


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