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    Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials

    This grant supports pilot studies to develop and test interventions or services for substance use and HIV prevention, requiring collaboration with stakeholders and a clear theory of change.

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    Funder: National Institutes of Health

    Due Dates (Anticipated): October 2026 (Full application deadline, projected)

    Funding Amounts: Not specified; typical NIH pilot/feasibility awards are modest and short-term; see program page for updates.

    Summary: Supports pilot and feasibility studies to prepare for substance use and HIV prevention intervention and services research trials.

    Key Information: This is a forecasted opportunity; applications are not yet being solicited.


    Description

    This forecasted opportunity from the National Institute on Drug Abuse (NIDA) at NIH aims to support pilot and feasibility studies that lay the groundwork for future efficacy, effectiveness, or services research trials in substance use and HIV prevention. The program encourages projects that develop, adapt, or test interventions to prevent substance misuse or progression to disorder; address substance use prevention, treatment, or recovery services (including comorbid pain, medical, and mental health disorders); or advance HIV eradication research, including implementation science in substance use settings and populations.

    Projects may:

    • Address information gaps
    • Strengthen stakeholder partnerships
    • Pilot test interventions or service models
    • Develop/adapt interventions, measures, materials, or methods for future trials

    Preliminary data is not required, but a well-defined theory of change or logic model is expected. Applicant teams must engage relevant end users (e.g., policymakers, practitioners, individuals with lived experience, families, youth, and community members) in the design, execution, and interpretation of the study.


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