NIH Pragmatic Trials Conducted in Health Care Systems
NIH will offer funding for large-scale trials in real-world health care settings to test and implement interventions, aiming to inform decision-makers about their effectiveness, risks, and benefits.
Funder: National Institutes of Health
Due Dates (Anticipated): February 2027 (full application deadline, projected)
Funding Amounts: Amounts not yet specified; large-scale, milestone-driven cooperative agreements expected.
Summary: Supports large pragmatic and implementation trials in healthcare systems to evaluate interventions in real-world clinical settings.
Key Information: This is a forecasted opportunity; applications are not yet being solicited.
Description
This upcoming funding opportunity from the National Institutes of Health (NIH) will support large-scale pragmatic and implementation trials conducted in real-world health care systems. The goal is to test the effectiveness of biomedical or behavioral interventions within routine clinical care, or to evaluate strategies for delivering such interventions. Projects funded under this program are intended to generate evidence that directly informs decision-makers—including patients, clinicians, administrators, policymakers, and payers—about the comparative benefits, burdens, and risks of interventions.
The program encourages applicants to:
- Select care settings where the target condition is commonly encountered (e.g., emergency departments, primary care, public health clinics).
- Involve multiple health system types (e.g., academic centers, federally qualified health centers, integrated networks, VA Medical Centers).
- Assess adaptation and implementation across different systems and geographic regions.
Trials should be embedded in routine care. Applicants may propose integrating interventions with established efficacy into health care settings or implementing system-level changes to improve health outcomes. The award mechanism will be a phased, milestone-driven cooperative agreement, supporting both planning and full trial execution phases.
