[National Institutes of Health](https://www.nih.gov)

February 2027 (full application deadline, projected)

Amounts not yet specified; large-scale, milestone-driven cooperative agreements expected.

Supports large pragmatic and implementation trials in healthcare systems to evaluate interventions in real-world clinical settings.

This is a forecasted opportunity; applications are not yet being solicited.

--- ## Description This upcoming funding opportunity from the National Institutes of Health (NIH) will support large-scale pragmatic and implementation trials conducted in real-world health care systems. The goal is to test the effectiveness of biomedical or behavioral interventions within routine clinical care, or to evaluate strategies for delivering such interventions. Projects funded under this program are intended to generate evidence that directly informs decision-makers—including patients, clinicians, administrators, policymakers, and payers—about the comparative benefits, burdens, and risks of interventions. The program encourages applicants to: - Select care settings where the target condition is commonly encountered (e.g., emergency departments, primary care, public health clinics). - Involve multiple health system types (e.g., academic centers, federally qualified health centers, integrated networks, VA Medical Centers). - Assess adaptation and implementation across different systems and geographic regions. Trials should be embedded in routine care. Applicants may propose integrating interventions with established efficacy into health care settings or implementing system-level changes to improve health outcomes. The award mechanism will be a phased, milestone-driven cooperative agreement, supporting both planning and full trial execution phases. --- ## Due Dates - February 2027 (full application deadline, anticipated/projected) *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Specific award amounts are not yet announced. - Awards will be made as cooperative agreements, supporting large-scale, phased, and milestone-driven trials. - Details on total program funding and individual award ceilings are expected when the Notice of Funding Opportunity is formally published. --- ## Eligibility Eligible applicants include: - State and county governments - Independent school districts - Native American tribal governments (Federally recognized and other) - Public housing authorities/Indian housing authorities - Nonprofits with 501(c)(3) status (excluding institutions of higher education) - Private institutions of higher education - For-profit organizations (including small businesses) - Eligible agencies of the Federal Government - U.S. territories or possessions - Faith-based or community-based organizations - Regional organizations - Non-domestic (non-U.S.) entities (foreign institutions) - Others as specified in the program announcement There is no cost-sharing or matching requirement. --- ## Application Process - This is a forecasted opportunity; applications are not being accepted at this time. - NIH is providing advance notice to allow potential applicants to develop collaborations and prepare responsive projects. - The formal Notice of Funding Opportunity (NOFO) will outline application instructions, review criteria, and submission procedures once released. - Interested investigators should monitor the [Grants.gov listing](https://www.grants.gov/search-results-detail/362108) and the NIH program page for updates. --- ## Additional Information - Projects must be designed to maximize real-world relevance and generalizability. - Trials should be conducted in routine care settings and may focus on system-level changes or integration of proven interventions. - The program uses a phased award structure with milestones for both planning and execution. --- ## External Links - [NIH Main Page](https://www.nih.gov) - [Forecasted Opportunity on Grants.gov](https://www.grants.gov/search-results-detail/362108) - [NIH Contact Page](https://www.nih.gov/about-nih/contact-nih) --- ## Contact Information | Contact | Email | Phone | Notes | |-----------------------------------|--------------------------------------------|--------------|--------------------------------------| | NCCIH Division of Extramural Research Program Officer | [NCCIHDERFunding@nih.gov](mailto:NCCIHDERFunding@nih.gov) | 301-496-4000 | Please contact via e-mail. |

NIH Pragmatic Trials Conducted in Health Care Systems

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