Systems Biology of Infection and Inflammation in Chronic Diseases (U19 Clinical Trial Not Allowed)
NIH supports systems biology research integrating clinical data, omics, artificial intelligence, and modeling to understand infection and inflammation in chronic diseases; clinical trials are not allowed.
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Funder: National Institutes of Health
Due Dates: January 18, 2027 (Earliest submission) | February 18, 2027 (Application)
Funding Amounts: $26 million total funding, approximately 10 awards, $2.5 million award ceiling; five-year projects
Summary: Supports systems biology centers integrating longitudinal clinical data, multiomics, AI, and modeling to understand infection, inflammation, and chronic diseases.
Key Information: Projects must use longitudinal human clinical samples with clinical data; clinical trials and HIV/AIDS studies are not allowed.
Description
This NIH program supports multidisciplinary centers investigating how infectious pathogens and inflammatory pathways influence the predisposition, onset, and progression of chronic diseases. Through U19 cooperative agreements, centers will integrate existing longitudinal patient cohorts, electronic health records, large-scale multiomics datasets, advanced AI, and computational modeling. Findings will be validated through laboratory studies, new approach methodologies, animal models, and real-world data analyses.
Applicants must propose either a Chronic and Infectious Diseases Systems Biology Center (CIDSB) or a Systems Biology Inflammation Center (SBI). The program seeks predictive models, new disease classifications, drug targets, diagnostic biomarkers, and approaches to more precise prevention and treatment. Centers will collaborate through their respective consortia to share protocols, technologies, and data, improve reproducibility, and disseminate systems biology resources.
