[ALS Association](https://www.als.org)

August 2026 (Letter of Intent) | October 2026 (Full proposal, by invitation)

Up to $400,000 total over 2 years (inclusive of direct and indirect costs; max 10% indirect)

Supports translational research to understand, predict, and prevent ALS, with emphasis on interventions before symptom onset.

This is a forecasted opportunity; all dates are projected and subject to confirmation.

--- ## Description The ALS Association's Prevention Grants program funds research aimed at preventing or delaying the onset of amyotrophic lateral sclerosis (ALS). The focus is on advancing translational science, developing interventions, and creating tools that can move the field toward actionable strategies for risk reduction and prevention. Projects should emphasize validation and translation—rather than basic discovery—with the goal of achieving clinical impact by 2030. The scope includes understanding ALS causes and risk factors, developing predictive tools, and creating interventions to prevent the disease before symptoms appear. --- ## Due Dates - **Letter of Intent deadline (anticipated):** August 2026 - **Full proposal deadline (by invitation, anticipated):** October 2026 *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - **Maximum award:** $400,000 total (inclusive of direct and indirect costs) over a 2-year period - **Indirect costs:** Limited to 10% of total direct costs - **All funds must be expended within the approved period of performance** --- ## Eligibility - **Eligible Individuals:** - Researchers with the skills, knowledge, and resources to carry out the proposed work - Senior postdoctoral fellows (≥3 years in current position; mentor letter required at full proposal) - Established investigators, early career investigators, and those outside the ALS field - Junior postdoctoral fellows are not eligible (refer to Milton Safenowitz Postdoctoral Fellowship instead) - **Eligible Organizations:** - U.S. and non-U.S. public and private non-profit entities (universities, hospitals, labs, government units) - U.S. and non-U.S. for-profit companies (biotech/pharma, other public/private entities) - **Collaborations:** Allowed and encouraged; one PI required, with collaboration letters at full proposal stage --- ## Application Process - **Phase 1: Letter of Intent** - Submit via [ProposalCentral](https://proposalcentral.com) - Content should include project title, PI and key personnel, institutions, scientific rationale, objectives, and translational impact - **Phase 2: Full Proposal** - By invitation only, following LOI review - Detailed application instructions provided at invitation - **Review Process:** - Peer review by an ad hoc Scientific Review Committee - Final funding decisions made by the ALS Association Board of Trustees - **Submission Platform:** [ProposalCentral](https://proposalcentral.com) --- ## Additional Information - **Scope:** Projects must have the potential to prevent ALS. Studies focused on ALS-FTD continuum are eligible. - **Topics of Interest:** - Tools for linking environmental exposures to ALS - Frameworks for translating risk knowledge into interventions - Preclinical/clinical drug development for ALS prevention - Studies on at-risk populations and prodromal syndromes (e.g., mild motor impairment) - Infrastructure for studying genetic/environmental risk interactions - **Out of Scope:** - Projects solely identifying new ALS genes or new environmental associations - **Reporting:** Semi-annual progress and annual expenditure reports required; final reports due within 90 days of project end - **Compliance:** All human/animal research must have appropriate regulatory approvals --- ## External Links - [ALS Association Prevention Grants Program Page](https://www.als.org/research/research-we-fund/our-awards-and-programs/prevention-grants-program) - [ALS Association Funding Opportunities](https://www.als.org/research/funding-opportunities) - [ProposalCentral Application Portal](https://proposalcentral.com) - [ALS Association Grants Policy Statement](https://www.als.org/Grants-Policy-Statement) - [2022 Prevention Grants RFA (PDF)](https://www.als.org/sites/default/files/2022-07/Prevention-RFA.pdf) --- ## Contact Information | Contact Type | Details | |----------------------|----------------------------------------------------------------| | General Inquiries | [researchgrants@als.org](mailto:researchgrants@als.org) | | Funder Website | [https://www.als.org](https://www.als.org) | | Application Support | [ProposalCentral User Guide](https://docs.proposalcentral.com/RegUser.pdf) | | Mailing Address | ALS Association, 1300 Wilson Boulevard, Suite 600, Arlington, VA 22209, USA | | Phone | +1 800-782-4747 |

Prevention Grants

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