Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)
This grant supports developing and testing innovative psychosocial interventions for mental disorders to accelerate translating research into therapies.
Funder: National Institutes of Health
Due Dates: June 17, 2025 | October 17, 2025 | February 19, 2026 | June 15, 2026 | October 15, 2026 | February 17, 2027 | June 15, 2027 | October 15, 2027
Funding Amounts: No budget cap; project period up to 3 years; budgets must reflect actual project needs. Total NIMH commitment (all related NOFOs): $27M in FY 2026.
Summary: Supports pilot clinical trials to develop and test innovative psychosocial interventions for mental disorders, emphasizing experimental therapeutics and target engagement.
Key Information: Clinical trial required; only applications proposing novel psychosocial interventions or targets are responsive; foreign and domestic applicants eligible.
Description
This opportunity, issued by the National Institute of Mental Health (NIMH), funds pilot clinical trials (R33 mechanism) to develop and test novel psychosocial therapeutic and preventive interventions for mental disorders. The focus is on accelerating the translation of basic, behavioral, cognitive, affective, and neuropsychological research into innovative interventions. Projects must use an experimental therapeutics approach, emphasizing the replication of target engagement and the association between target engagement and clinical outcomes. Both standalone novel interventions and novel augmentations to established interventions are eligible, provided the target or strategy is empirically justified and innovative.
