PTAC Research Grant
Forecasted
PTAC Research Grant supports independent investigators’ basic research into restoring CFTR function or repairing or replacing the defective gene to inform therapies for people with cystic fibrosis.
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Funder: Cystic Fibrosis Foundation
Due Dates (Anticipated): May 2027 (Full application deadline)
Funding Amounts: Up to $150,000 per year, plus up to 12% indirect costs, for up to two years
Summary: Supports basic research that could advance therapies to restore CFTR function or repair or replace the defective CFTR gene.
Key Information: Applicants must be independent investigators; projects must address a Path to a Cure research area.
Description
The Cystic Fibrosis Foundation’s Path to a Cure (PTAC) Research Grant supports basic science that could inform therapies for people with cystic fibrosis whose CFTR variants are not served by existing small-molecule modulators. Projects may investigate foundational concepts, strategies, tools or technologies to restore CFTR protein function or repair or replace the defective gene. Proposals generally must be hypothesis-driven and supported by sufficient preliminary data, although development of useful tools or reagents may also be considered.
Priority topics include airway and submucosal-gland cells, nonsense-mutation readthrough, gene insertion, targeted delivery of nucleic acid therapies, delivery of large gene-editing components, immune responses to genetic therapies, and in vitro assays of CFTR restoration. Work centered on infection, airway hydration or non-lung manifestations belongs in the foundation’s general Research Award program.
