Funder: Cystic Fibrosis Foundation
Due Dates: May 12, 2026 (Application) | December 8, 2026 (Fall full application, 5 p.m. Eastern)
Funding Amounts: Up to $150,000 per year, plus 12% indirect costs, for up to two years
Summary: Supports basic science advancing therapies to restore CFTR function or repair or replace CFTR variants not served by existing modulators.
Key Information: Each laboratory—not each PI—may submit only one application per cycle (excluding training awards).
Description
The Cystic Fibrosis Foundation’s Path to a Cure (PTAC) Research Grant supports basic science that could enable therapies restoring CFTR function or repairing or replacing defective CFTR genes. It addresses unmet needs among people whose mutations do not respond to modulators, produce insufficient protein, or block protein synthesis, and people unable to tolerate or take approved modulators.
The program funds foundational concepts, strategies, tools, methods, and technologies that could inform new therapies. Proposals must generally be hypothesis-driven and supported by sufficient preliminary data. Tool- or reagent-development projects that are not typically hypothesis-driven may also be considered if they facilitate research toward a cure. Findings are intended to help investigators pursue subsequent support from agencies such as the NIH.
