[Coefficient Giving](https://coefficientgiving.org/apply-for-funding)

May 11, 2026 (Application deadline)

Up to $20 million USD total; no maximum per proposal; multiple awards expected.

Supports late-stage clinical trials repurposing generic drugs for neglected, high-burden diseases in low- and lower-middle-income countries.

Letters of interest required; open to global applicants with clinical research experience.

--- ## Description This grant opportunity funds rigorous late-stage clinical trials investigating the repurposing of generic drugs for new indications, specifically targeting high-burden, neglected diseases affecting low- and lower-middle-income countries (LMICs). The initiative aims to accelerate patient access to effective, affordable treatments by leveraging the established safety profiles and supply chains of generic medicines. Coefficient Giving seeks to support research projects that can provide strong clinical evidence of efficacy for repurposed therapies where commercial incentives are lacking, ultimately addressing unmet medical needs in resource-limited settings. --- ## Due Dates - May 11, 2026: Application deadline (submissions must be received by 11:59pm U.S. Pacific Time) --- ## Funding Amount - Total available budget: up to $20 million USD for this call. - No maximum size for individual proposals; multiple projects may be funded. - Preference for trials that can be completed within a five-year period. - Co-funding with other sources is possible if the budget is exceeded by high-quality proposals. --- ## Eligibility - **Eligible applicants:** Researchers and institutions worldwide with past or current experience in human clinical research. - **Eligible interventions:** Repurposed therapies (generic drugs, nutraceuticals, supplements, indigenous medicine, combination therapies, vaccines) already approved/recognized as safe for human use by a WHO-Listed Authority (e.g., U.S. FDA, EMA). - **Focus:** Proposals must target new indications for which the therapy is not already approved or widely used in clinical practice; includes population expansion and combination therapies. - **Institutional requirements:** Must have a research Institutional Review Board, Ethics Review Committee, or similar oversight in place. - **Compliance:** Proposed plans must adhere to Good Laboratory Practice (GLP), Good Clinical Practice (GCP), and Good Laboratory and Clinical Practice (GLCP) standards as set by WHO or other regulatory agencies. - **Geographic focus:** Projects must aim to benefit patients in low- and lower-middle-income countries as defined by the [World Bank](https://datatopics.worldbank.org/world-development-indicators/the-world-by-income-and-region.html). --- ## Application Process - **Letter of Interest (LOI):** Submit a Word document (max 3 pages) via the [online application form](https://fillout.coefficientgiving.org/t/5g9yss4Q9eus?campaign=recdUwhAbF5d0lckU). - **LOI should include:** - Proposed generic therapy and new indication(s) - Rationale and potential benefit - Supporting evidence (with references) - Current standard of care in LMICs - Research team and clinical trial experience - (If known) Proposed trial design and indicative budget - Status of other funding approaches - **Review process:** - LOIs are rated by Coefficient Giving staff (with possible input from expert consultants under NDA). - Top-rated LOIs may be invited to further discussions and, potentially, to submit a full proposal. - Applicants will be notified of their status approximately 4–6 weeks after LOI submission. - **Outcome categories:** 1. Strong Interest (invitation to discuss full proposal) 2. Reserve List (pending budget) 3. Unsuccessful (no feedback provided at this stage) --- ## Additional Information - Preference for trials with high potential for rapid uptake in LMICs and significant impact on disease burden. - Projects unlikely to receive funding from other sources are especially encouraged. - Early-stage proof-of-concept ideas may be better suited for [Cures Within Reach](https://www.cureswithinreach.org/programs/regrow-pilot/). - No restrictions on applicant location, provided the project meets eligibility criteria. --- ## External Links - [Program page and full RFP details](https://coefficientgiving.org/funds/science-and-global-health-rd/request-for-proposals-generic-drug-repurposing) - [Apply online (submission form)](https://fillout.coefficientgiving.org/t/5g9yss4Q9eus?campaign=recdUwhAbF5d0lckU) - [World Bank country income classifications](https://datatopics.worldbank.org/world-development-indicators/the-world-by-income-and-region.html) - [Funder homepage](https://coefficientgiving.org/apply-for-funding) --- ## Contact Information | Purpose | Contact | |------------------------|-----------------------------------------------------------| | General inquiries | [repurposingrfp@coefficientgiving.org](mailto:repurposingrfp@coefficientgiving.org) | | Funder contact page | [Contact Coefficient Giving](https://coefficientgiving.org/contact) |

Request for Proposals: Generic Drug Repurposing

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