Funder: Jeffrey Modell Foundation
Due Dates: March 12, 2025 (Letter of Intent) | July 23, 2025 (Full Application, invited only) | Rolling (Specific Defect & C.H.I.L.D.R.E.N! grants)
Funding Amounts: Up to $250,000 over 2 years for Translational Research; up to $50,000 over 2 years for Specific Defect Research; up to $50,000 over 2 years for C.H.I.L.D.R.E.N! grants; up to $10,000 for G.E.N.I.E. Physician Education grants.
Summary: Supports research and educational initiatives to improve awareness, diagnosis, and treatment of Primary Immunodeficiency (PI) worldwide.
Key Information: Limited submission; two-step application for Translational Research grant; rolling submissions for other programs; international applicants encouraged.
Description
The Jeffrey Modell Foundation (JMF) offers multiple grant programs aimed at advancing research and education in Primary Immunodeficiency (PI). These grants support innovative studies, educational initiatives, and clinical applications to improve diagnosis, management, and treatment of PI globally. JMF also provides educational materials and tools such as the SPIRIT® Analyzer Software to aid healthcare professionals in identifying undiagnosed PI patients.
Grant Programs
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Translational Research Program
Focuses on novel and innovative investigations in PI with translational potential to clinical application. Emphasizes genotype-phenotype correlations, early diagnosis, and therapeutic strategies. Awards up to $250,000 over two years, with a two-step application process requiring a Letter of Intent (LOI) and invited full application.
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Specific Defect Research Program
Supports research on mechanisms and clinical presentation of specific immune defects. Grants up to $50,000 over two years, awarded on a rolling basis. Applicants gain access to JMF’s international patient genotype database for collaboration.
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C.H.I.L.D.R.E.N!® Grant
Targets research focused on children with PI, especially addressing healthcare disparities in developing countries. Supports studies on immunological disorders, infectious diseases, infant mortality, and vaccine development. Awards up to $25,000 per year for two years, with rolling submissions.
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G.E.N.I.E. Physician Education Grant
Funds physician education programs to promote PI awareness and global collaboration. Supports continuing education, grand rounds, scientific publishing, and local seminars. Awards up to $10,000 annually on a rolling basis.
Additional Resources
- Educational Materials for physicians, nurses, and researchers to increase PI awareness and improve clinical care.
- SPIRIT® Analyzer Tool, a software for screening electronic health records to identify patients at risk for PI.
- Access to the Jeffrey Modell Centers Network (JMCN), a global network of over 400 centers specializing in PI diagnosis and treatment.
- The “Jeffrey’s Insights” Genetic Sequencing Program offers no-cost genetic sequencing to patients with PI but no genetic diagnosis, improving clinical management.
Due Dates
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Translational Research Program
- Letter of Intent Deadline: March 12, 2025
- Full Application Deadline (invited only): July 23, 2025
- Grant Awards Announced: November 30, 2025
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Specific Defect Research Program
- Rolling submissions accepted year-round
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C.H.I.L.D.R.E.N!® Grant
- Rolling submissions accepted year-round
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G.E.N.I.E. Physician Education Grant
- Rolling submissions accepted year-round
Funding Amount
- Translational Research Program: Up to $250,000 total over two years (max $125,000 per year). Funds cover direct costs only; no institutional overhead.
- Specific Defect Research Program: Up to $50,000 total over two years (max $25,000 per year). Direct costs only.
- C.H.I.L.D.R.E.N!® Grant: Up to $25,000 per year for two years. Direct costs only.
- G.E.N.I.E. Physician Education Grant: Up to $10,000 for one year. Funds cannot be used for travel or overhead.
Eligibility
- Open to international and U.S. investigators with expertise or strong interest in Primary Immunodeficiency research.
- Both established and young investigators encouraged to apply.
- Investigators not currently funded by NIH are especially encouraged for the Translational Research Program.
- Only one active grant per investigator allowed at a time for the Translational Research Program.
- Applicants for G.E.N.I.E. must be enrolled in a fellowship or higher.
Application Process
Translational Research Program
- Step 1: Submit a Letter of Intent (LOI) via ProposalCentral by March 12, 2025.
- LOI form: Access LOI Form
- Registration guide: How to Register
- Step 2: Invited applicants submit a full application by July 23, 2025.
- Application materials include: ProposalCentral form, detailed research proposal (max 6 pages), CV/biosketch (max 5 pages), and optional letters of support.
- Submit applications and inquiries to research@jmfworld.org. Paper submissions accepted at:
Jeffrey Modell Foundation
780 Third Avenue, 47th Floor
New York, NY 10017
Fax: 212-764-4180
Specific Defect Research Program
- Applications accepted on a rolling basis.
- Required materials: completed application form (download here), research proposal (3-4 pages), budget and justification (max 2 pages), CV/biosketch (max 5 pages).
- Submit via email to research@jmfworld.org or by mail/fax as above.
C.H.I.L.D.R.E.N!® Grant
- Rolling submissions accepted.
- Required materials: completed application (download here), research proposal (3-4 pages), budget and justification (max 2 pages), CV/biosketch (max 5 pages).
- Submit via email to research@jmfworld.org or by mail/fax as above.
G.E.N.I.E. Physician Education Grant
- Rolling submissions accepted.
- Required materials: project summary, completed application (download here), budget justification, CV/biosketch, and at least one letter of support.
- Submit via email to genie@jmfworld.org.
Additional Information
- The Jeffrey Modell Foundation also offers educational resources, clinical trial information, and tools like the SPIRIT® Analyzer Software to support PI diagnosis and management.
- The Foundation’s network includes over 400 centers worldwide, facilitating collaboration and data sharing.
- The “Jeffrey’s Insights” genetic sequencing program provides no-cost sequencing to PI patients without a genetic diagnosis, improving treatment outcomes.
- Applicants are encouraged to review historic awardees and proposal titles for guidance: Historic Awardees List.
- Only direct costs are supported; institutional overhead is not covered.
- For re-submissions, include an updated revision statement; only one re-submission per application is allowed.
External Links
Contact Information
| Contact Role | Contact Details |
|---|
| General Research Inquiries | research@jmfworld.org |
| G.E.N.I.E. Grant Inquiries | genie@jmfworld.org |
| Phone | 212-819-0200 |
| Mailing Address | Jeffrey Modell Foundation
780 Third Avenue, 47th Floor
New York, NY 10017 USA |
| Fax | 212-764-4180 |