[National Institutes of Health](https://www.nih.gov)

September 28, 2028 (Full application)

Estimated total program funding: $5,000,000; ~6 awards expected; individual award ceiling not specified.

Supports development, improvement, or characterization of broadly applicable research models and methodologies for studying human health and disease.

--- ## Description This funding opportunity from the NIH Office of Research Infrastructure Programs (ORIP) seeks applications for research projects focused on the development, characterization, or improvement of research models—including new approach methodologies (NAMs)—and related biological materials for studying human health and diseases. Projects should aim to create resources that are relevant across multiple NIH Institutes or Centers (ICs) and address diseases or processes impacting multiple organ systems. The goal is to enhance the availability and utility of models and materials that have broad scientific impact and support a wide range of research disciplines. Proposals that focus only on a single disease, a narrow research area, or the interests of one NIH IC are not eligible. --- ## Due Dates - Full application deadline: September 28, 2028 --- ## Funding Amount - Estimated total program funding: $5,000,000 - Approximately 6 awards expected - No specific individual award ceiling or floor stated - No cost sharing or matching requirement --- ## Eligibility - Eligible applicants include: - State, county, city, or township governments - Public and private institutions of higher education - Native American tribal governments (federally recognized) - Nonprofits with or without 501(c)(3) IRS status (excluding higher education institutions) - For-profit organizations (including small businesses) - Other organizations as specified in the NOFO - Foreign organizations and foreign components are **not eligible**. - Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are **not eligible**. - Refer to Section III of the NOFO for detailed eligibility information. --- ## Application Process - Applications must be submitted through [Grants.gov](https://www.grants.gov/search-results-detail/359648). - Prepare materials according to the instructions in the Notice of Funding Opportunity (NOFO). - Ensure your project aligns with the requirement for broad applicability across multiple NIH ICs and multiple organ systems. - Contact ORIP for any questions regarding application requirements. --- ## Additional Information - Projects focusing narrowly on a single disease or primarily serving one NIH IC will not be considered. - The program is designed to support resources that benefit a broad segment of the NIH-supported research community. - Clinical trials are **not allowed** under this opportunity. --- ## External Links - [Full opportunity details and application](https://www.grants.gov/search-results-detail/359648) - [NIH Office of Research Infrastructure Programs (ORIP)](https://orip.nih.gov/) - [NIH Home Page](https://www.nih.gov) --- ## Contact Information | Contact | Email | |---------------------------------------------|-----------------------------------| | Office of Research Infrastructure Programs (ORIP) | [ORIPDCM@mail.nih.gov](mailto:ORIPDCM@mail.nih.gov) |

Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

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