[National Institutes of Health (NIH)](https://www.nih.gov/)

January 25, 2026 (Forecasted)

Estimated total program funding: $5,000,000; approximately 6 awards expected

Supports development, characterization, or improvement of broadly applicable research models and related materials for studying human health and disease.

Clinical trials are not allowed; opportunity is forecasted—details may change.

--- ## Description This funding opportunity, administered by the NIH Office of Research Infrastructure Programs (ORIP), aims to support resource-related research projects that develop, characterize, or improve research models and associated biological materials relevant to human health and disease. The focus is on projects that are broadly applicable to the interests of at least two NIH Institutes or Centers and address diseases or processes impacting multiple organ systems. The grant encourages the creation or enhancement of models, development of new approach methodologies (NAMs), and improved access to or information about such models. Funded projects should have the potential for significant impact and utility across the biomedical research community. Examples of suitable projects include: - Development of mutant or transgenic models - Creation of NAMs, antibodies, or other reagents - Development of information resources and informatics tools - Methods to improve cryopreservation of genetic stocks - Techniques to advance regenerative medicine in models - Approaches to enhance rigor and reproducibility in animal research Applicants must demonstrate the need for their proposed resource, its anticipated impact, and plans for distribution, accessibility, and long-term availability. A replication and validation plan for developed models or resources is required. --- ## Due Dates - Estimated application due date: January 25, 2026 (Forecasted) *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Estimated total program funding: $5,000,000 - Approximately 6 awards expected - No cost sharing or matching requirement --- ## Eligibility Eligible applicants include: - State governments - County governments - Public and state-controlled institutions of higher education - Private institutions of higher education - Federally recognized Native American tribal governments - Native American tribal organizations (other than federally recognized) - Nonprofits with 501(c)(3) status (excluding higher education institutions) - For-profit organizations (including small businesses) --- ## Application Process - This is a forecasted opportunity; the official Notice of Funding Opportunity (NOFO) will be published at a later date. - Potential applicants are encouraged to begin developing collaborations and project concepts now. - The application will utilize the NIH R24 activity code. - Detailed instructions and requirements will be provided in the forthcoming NOFO. --- ## Additional Information - Projects must be relevant to the interests of two or more NIH Institutes or Centers. - Applications should describe the need, impact, and plans for resource utilization and dissemination. - Clinical trials are not permitted under this opportunity. --- ## External Links - [Grant Forecast on Grants.gov](https://www.grants.gov/search-results-detail/359648) - [NIH Office of Research Infrastructure Programs (ORIP)](https://orip.nih.gov/) --- ## Contact Information | Name | Email | Phone | Office | |-------------|-----------------------------|--------------|------------------------------------------------| | Sige Zou, PhD | [sige.zou@nih.gov](mailto:sige.zou@nih.gov) | 301-435-0749 | Office of Research Infrastructure Programs (ORIP) | ---

Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

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