Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
NIH offers $300,000 to $5 million to groups of NIH-supported investigators to purchase or upgrade a shared research instrument or integrated instrumentation system.
Funder: National Institutes of Health
Due Dates: July 27, 2026 (Applications) | July 1, 2027 (Applications) | July 1, 2028 (Applications)
Funding Amounts: $300,000–$5,000,000 for one year; no cap on total instrument cost
Summary: Supports groups of NIH-funded investigators purchasing or upgrading a single shared research instrument or integrated instrumentation system.
Key Information: At least three Major Users must each lead a distinct, active NIH research award.
Description
The NIH Shared Instrumentation Grant (SIG) Program, administered through the Office of Research Infrastructure Programs (ORIP), consolidates the Shared, High-End, and Basic Instrumentation Grant programs. It supports the purchase or upgrade of a single state-of-the-art, commercially available instrument or integrated system for NIH-supported research. Shared use must promote efficient research operations, rigorous and reproducible measurements, collaboration, and benefits to broader research communities.
Eligible technologies include imaging systems, microscopes, spectrometers, flow cytometers, cell sorters, sequencers, X-ray diffractometers, and biomedical research computing systems. Instruments should be housed in a core facility or shared resource whenever possible. ORIP may prioritize instruments supporting human-based research, new approach methodologies, artificial intelligence, and emerging technologies, including systems producing physical or mechanical outputs rather than conventional digital data.
