Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Data Mining and Functional Validation (R21 Clinical Trial Not Allowed)
The SCORCH program funds research to identify cellular responses related to HIV and Substance Use Disorder and validate their biological roles.
This grant is no longer accepting proposals
National Institutes of Health has archived this opportunity.
Funder: National Institutes of Health (NIH)
Due Dates: March 19, 2025 (AIDS-related proposals) | November 20, 2025 (Final application deadline)
Funding Amounts: Up to $275,000 direct costs over 2 years; no more than $200,000 in any single year.
Summary: Supports data mining and functional validation of single cell datasets to uncover molecular mechanisms of HIV/ART and substance use disorder (SUD) interactions.
Key Information: Clinical trials are not allowed; project duration up to 2 years.
Description
This funding opportunity supports innovative research projects that utilize data mining of single cell datasets to identify cell types, transcripts, enhancers, or transcriptional networks involved in molecular responses relevant to HIV infection, antiretroviral therapy (ART), and substance use disorders (SUD). It also supports functional validation studies (e.g., epigenomic or transcriptomic manipulation, high-throughput screening) to confirm the biological roles of these identified factors. The program is intended to advance understanding of the interplay between HIV, ART, and addictive substances at the single-cell level, with the ultimate goal of informing new therapeutic strategies.
Eligible projects may include mining of existing single cell or spatial genomics datasets (including those from the SCORCH program, BRAIN Initiative, HuBMAP, or investigator-generated data), cross-species analyses, integration with other molecular datasets, and functional characterization using modern genomic tools. Interdisciplinary teams with expertise in single cell analysis, HIV, and addiction neuroscience are encouraged to apply.
