Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)
This grant funds the continued POWERS study to complete clinical trials and analyze why people regain weight differently after losing it.
Funder: National Institutes of Health
Due Dates: November 17, 2026 (Application)
Funding Amounts: One award for up to 3 years; up to $3.85 million in FY2027 and $3.25 million annually in FY2028–FY2029
Summary: Supports completion of the POWERS clinical trial and analysis of data and biospecimens to understand weight regain following lifestyle-induced weight loss.
Key Information: Only the University of Pittsburgh, as the POWERS Data Coordinating Center, is eligible to apply.
Description
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of NIH, is offering single-source support to continue the Physiology of the Weight Reduced State (POWERS) study. Launched in 2021, this multicenter clinical trial investigates physiological processes underlying individual differences in weight regain after a lifestyle weight-loss intervention. It measures body composition, energy expenditure, and energy intake before and after weight loss and during a year of unsupervised weight maintenance.
This opportunity supports the consortium’s Data Coordinating Center in completing recruitment, the intervention, study visits, and biospecimen collection. Subsequent work includes data curation and analysis, biospecimen testing, data sharing, and dissemination through publications. Funding uses a U01 cooperative agreement with substantial NIH scientific or programmatic involvement.
