Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)
NIH supports multidisciplinary centers to solve biological structures relevant to preventing, treating, and curing HIV and other infectious diseases, while sharing resources and training scientists.
Funder: National Institutes of Health
Due Dates: April 28, 2027 (Earliest submission) | May 28, 2027 (Application deadline)
Funding Amounts: $3.5 million award ceiling; five-year projects; $33 million total planned funding
Summary: Supports multidisciplinary centers solving complex biological structures to advance prevention, treatment, and cures for HIV and other infectious diseases.
Key Information: Applications must combine basic and translational research, include atomic-resolution structural determination, and exclude clinical trials.
Description
The National Institute of Allergy and Infectious Diseases (NIAID), with participation from the Office of AIDS Research (OAR), supports multidisciplinary, multi-institutional consortia of structural biologists, microbiologists, and associated experts through U54 cooperative agreements. Centers will investigate complex molecular structures and host-pathogen interactions to inform diagnostics, preventive interventions, therapeutics, and curative strategies for human infectious diseases.
The program emphasizes challenging, incompletely characterized macromolecular complexes, new technologies, computational modeling, and biological validation of structural findings. Supported work may include structure-guided intervention design and mechanisms of resistance or intervention failure, but not end-to-end preclinical development. Centers must also build external collaborations, share resources and services, and train students, postdoctoral fellows, and early-career investigators.
