[Breakthrough T1D](https://www.breakthrought1d.org)

November 12, 2025 (Letter of Intent)

Up to $3,000,000 total for up to 3 years (Strategic Research Agreements); actual budget and duration may vary by project.

Supports research on clinically relevant questions about ketones and continuous ketone monitoring to improve care and outcomes for people with type 1 diabetes.

--- ## Description This funding opportunity from Breakthrough T1D supports research projects that address clinically relevant questions about ketones and the use of continuous ketone monitoring (CKM) in type 1 diabetes (T1D). The goal is to clarify how ketone dynamics and CKM data can inform clinical care, help prevent complications such as diabetic ketoacidosis, and guide treatment decisions for individuals living with T1D. Projects should advance understanding of the role of ketones and CKM in improving outcomes and optimizing care for people with T1D. Both mechanistic and patient-oriented studies are encouraged, with an emphasis on clinical relevance and potential to impact practice. --- ## Due Dates - November 12, 2025: Letter of Intent (LOI) deadline Applicants must submit an LOI by this date to be considered for invitation to submit a full proposal. Additional deadlines for full proposals and anticipated award start dates will be communicated to invited applicants. --- ## Funding Amount - Applicants may request up to **$3,000,000 total for up to 3 years** under the Strategic Research Agreement (SRA) mechanism. - The actual budget should be commensurate with project scope and objectives; smaller budgets are also considered. - Indirect costs are capped at 10% of direct costs for SRAs. - For-profit applicants may apply under the Industry Discovery & Development Partnership (IDDP) mechanism, which requires matching funds and has different indirect cost rules. - Allowable costs, budget justification, and duration must follow the guidelines set in the [Breakthrough T1D Grant Handbook](https://www.breakthrought1d.org/granthandbook/). --- ## Eligibility - **Applicants:** Must hold an MD, PhD, DMD, DVM, DO, or equivalent, and have a faculty or equivalent position at a college, university, medical school, company, or other research facility. - **Institutions:** Domestic and foreign non-profit organizations, public and private universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government are eligible. - **For-profit organizations:** May apply under the IDDP mechanism (see Grant Handbook for requirements). - Breakthrough T1D encourages applications from diverse backgrounds and supports proposals from underrepresented groups in science. - There are no citizenship restrictions. --- ## Application Process 1. **Review the Grant Handbook** for eligibility, compliance, and administrative requirements. 2. **Download and review the RFA** ([CKM RFA PDF](https://www.breakthrought1d.org/wp-content/uploads/2025/10/RFA_CKM_Call_Doc.pdf)) for specific scientific aims, eligibility, and required application sections. 3. **Prepare and submit a Letter of Intent (LOI)** via the [RMS360 application portal](https://breakthrought1d.smartsimple.us/) by November 12, 2025. 4. If invited, **prepare and submit a full proposal** by the deadline communicated by Breakthrough T1D. 5. Proposals must follow formatting, budget, and documentation requirements detailed in the RFA and Grant Handbook. 6. Human subjects research must comply with relevant ethical guidelines and include appropriate documentation. --- ## Additional Information - Projects must be relevant to T1D and aligned with Breakthrough T1D’s research strategy. - Review criteria include scientific merit, clinical relevance, innovation, feasibility, and potential for impact on T1D care. - Awards are subject to Breakthrough T1D’s standard terms and conditions, including reporting, data sharing, and compliance requirements. - For collaborative or multi-site studies, applicants should describe site capacity and recruitment strategies. --- ## External Links - [Funding Opportunity Details](https://www.breakthrought1d.org/explore-research/funding-opportunities/#psychosocial-fellowships-not-offered-details-below) - [CKM RFA PDF](https://www.breakthrought1d.org/wp-content/uploads/2025/10/RFA_CKM_Call_Doc.pdf) - [Breakthrough T1D Grant Handbook](https://www.breakthrought1d.org/granthandbook/) - [RMS360 Application Portal](https://breakthrought1d.smartsimple.us/) - [Funding Opportunities Overview](https://www.breakthrought1d.org/explore-research/funding-opportunities/) --- ## Contact Information | Name/Role | Email | Notes | |----------------------------|------------------------------------------|-----------------------------------------| | General inquiries | [Contact form](https://www.breakthrought1d.org/contact-us/) | Use for administrative questions | | Strategic Fit/Scientific | cackeifi@BT1D.org | Dr. Courtney Ackeifi, Senior Scientist | | Administrative | smukerjee@BT1D.org | Dr. Sanjukta Mukerjee, Program Admin | For specific questions about the CKM RFA or scientific scope, refer to the RFA for additional contact details. ---

Studies Addressing Clinically Relevant Questions About Ketones And The Use Of Continuous Ketone Monitoring In Type 1 Diabetes

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