Targets to Therapies: Mitochondrial Target Validation
Funds research to validate mitochondrial targets for Parkinson’s disease through mechanistic studies, biomarker development, and translational research.
Funder: Michael J. Fox Foundation for Parkinson's Research (https://www.michaeljfox.org)
Due Dates: Not specified (see program page for current or future calls)
Funding Amounts: Typical awards range from $250,000 to $2,000,000 per project; duration varies by scope.
Summary: Supports research validating mitochondrial targets for Parkinson’s disease, focusing on mechanistic studies, biomarker development, and translational data.
Key Information: Open Science Policy applies—research outputs must be openly shared.
Description
This program funds research to strengthen the scientific foundation for mitochondrial targets that are highly relevant to Parkinson’s disease. The aim is to clarify the human relevance of mitochondrial targets, define mechanisms in Parkinson’s-specific contexts, establish target engagement, and develop tools and assays that support therapeutic development. Activities supported include target modulation studies in cell and animal models, linking target biology to patient samples, clarifying mechanisms of action, preclinical biomarker validation, and assessing biological safety. The program emphasizes projects that fill critical knowledge gaps and generate reproducible, translatable data to guide therapeutic decisions.
