Targets to Therapies: Mitochondrial Target Validation
Targets to Therapies: Mitochondrial Target Validation supports researchers studying mitochondrial targets to build evidence that guides therapeutic decisions for Parkinson’s disease.
Funder: Michael J. Fox Foundation for Parkinson's Research
Due Dates: Not specified
Funding Amounts: Not specified
Summary: Supports mitochondrial target validation research that builds evidence for therapeutic decisions in Parkinson’s disease.
Key Information: MJFF’s Open Science Policy requires research outputs to be openly shared, free to access, and assigned persistent identifiers.
Description
The Michael J. Fox Foundation for Parkinson’s Research (MJFF) supports projects that build a robust evidence base for mitochondrial targets with high potential relevance to Parkinson’s disease. The program funds work to clarify human relevance, define mechanisms in Parkinson’s-relevant contexts, establish target engagement, and develop enabling tools and assays.
Supported research includes target modulation in cell and animal models, linking target biology to Parkinson’s patient samples, clarifying therapeutic mechanisms of action, and characterizing biological safety in animal models. Projects may also identify and test biomarkers for preclinical therapeutic validation and patient stratification. MJFF prioritizes work that addresses known target gaps and generates reproducible, translatable data to move a defined target toward a therapeutic decision point.
