[Breakthrough T1D](https://www.breakthrought1d.org)

January 28, 2026 (Letter of Intent)

Maximum award up to $3,000,000 total for up to 3 years; budget may be smaller and must match project scope.

Supports translational research to develop, enhance, and monitor vascularization strategies for durable islet replacement therapies in type 1 diabetes.

--- ## Description This opportunity from Breakthrough T1D supports translational research aimed at improving the vascularization of islet replacement therapies for type 1 diabetes. The focus is on developing, validating, and advancing strategies to define, enhance, and monitor the vascular support of islet grafts or devices, with the goal of ensuring their long-term survival and function. Projects may address characterization of vascularization in islet implants, enhancement of neovascularization and blood supply, and noninvasive or minimally invasive monitoring of vascular status. Emphasis is placed on innovative, clinically translatable approaches. --- ## Due Dates - Letter of Intent (LOI) deadline: January 28, 2026 Additional program dates (e.g., full proposal deadlines, review periods) will be communicated to invited applicants. --- ## Funding Amount - Maximum award: Up to $3,000,000 total for up to 3 years - The budget must be commensurate with the scope and objectives of the proposed research; smaller budgets are encouraged if justified. - Indirect costs are capped at 10% for non-profit institutions; not permitted for for-profit (IDDP) applications. --- ## Eligibility - **Institutions:** Domestic and foreign non-profit organizations, public and private universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government. - **Applicants:** Must hold an M.D., D.O., D.M.D., D.V.M., Ph.D., or equivalent and have a faculty position or equivalent at a college, university, medical school, or research facility. - **For-profit entities:** May apply under the Industry Discovery & Development Partnership (IDDP) mechanism, which requires company matching funds and has additional requirements. - Breakthrough T1D encourages proposals from all qualified individuals and supports diversity among applicants. --- ## Application Process - **Step 1:** Review the [Grant Handbook](https://www.breakthrought1d.org/granthandbook/) and the specific [Vascularization RFA](https://www.breakthrought1d.org/wp-content/uploads/2025/12/RFA_Vascularization_Call-Document.pdf) for detailed requirements. - **Step 2:** Submit a Letter of Intent (LOI) by January 28, 2026, via the [RMS360 portal](https://breakthrought1d.smartsimple.us/). - Use the LOI template provided in RMS360. - LOI should be no more than 2 pages. - **Step 3:** If invited, submit a full proposal using the provided templates in RMS360. - **Step 4:** Attend the informational webinar (optional but recommended) for guidance and Q&A. - **Step 5:** Applications involving human subjects must include supplemental information as described in the Grant Handbook. --- ## Additional Information - Projects must be milestone-driven, with regular reporting and interaction with Breakthrough T1D scientific staff. - Collaborative approaches, including academic-industry partnerships, are encouraged. - For-profit applicants (IDDP) must provide matching funds and should contact Breakthrough T1D staff before submission. - All funded research must align with Breakthrough T1D’s mission and research strategy. - Detailed review criteria and allowable costs are outlined in the RFA and Grant Handbook. --- ## External Links - [Breakthrough T1D Funding Opportunities](https://www.breakthrought1d.org/explore-research/funding-opportunities/) - [Vascularization RFA (PDF)](https://www.breakthrought1d.org/wp-content/uploads/2025/12/RFA_Vascularization_Call-Document.pdf) - [Grant Handbook](https://www.breakthrought1d.org/granthandbook/) - [RMS360 Application Portal](https://breakthrought1d.smartsimple.us/) - [Webinar Registration](https://breakthrought1d-org.zoom.us/webinar/register/WN_BMGgFL2dQb6oeCG54km-Vw#/registration) - [Privacy Policy](https://www.breakthrought1d.org/privacy/) --- ## Contact Information | Purpose | Contact Name | Email | |--------------------------|-------------------------|-------------------------------------| | Strategic Fit/Scientific | Courtney Ackeifi, PhD | cackeifi@BT1D.org | | Administrative | Sanjukta Mukerjee, PhD | smukerjee@BT1D.org | | General Inquiries | Breakthrough T1D Contact | [Contact Form](https://www.breakthrought1d.org/contact-us/) | ---

Translational Strategies to Define, Enhance, and Monitor Vascularization for Durable Islet Replacement Therapies

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