Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)

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Description

This opportunity allows Principal Investigators (PIs) with active NIH research grants or cooperative agreements to request urgent competitive revision (supplement) funding. The purpose is to address immediate needs related to a specific public health crisis that could not have been anticipated at the time of the original or renewal application, or the most recent progress report. Only applications submitted in response to an Urgent Notice of Special Interest (NOSI) published by an NIH Institute or Center (IC) are eligible. The supplement must be within the scope and project period of the parent award.

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Due Dates

• Expiration Date: October 26, 2025
• Application Deadlines: Vary by Institute/Center and specific Urgent Guide Notice. Applicants should consult the relevant NOSI for exact deadlines.
• Note: The funding opportunity was updated on March 31, 2025, to align with agency priorities. Review the full announcement and NOSIs before applying.

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Funding Amount

• Budget: No specific budget cap; requests must be justified and reflect the actual needs of the proposed urgent project.
• Project/Budget Period: Must be within the currently approved project period of the parent award.
• Number of Awards: Contingent on NIH appropriations and the number of meritorious applications.

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Eligibility

• Eligible Applicants:
  • Holders of active NIH research grants or cooperative agreements (see FOA and relevant NOSI for eligible activity codes).
  • Organizations administering eligible parent awards, including:
    • Public and private higher education institutions
    • Nonprofits (with or without 501(c)(3) status)
    • For-profit organizations (including small businesses)
    • State, county, city, township, and special district governments
    • Tribal governments and organizations
    • Public housing authorities
    • Independent school districts
    • Faith-based and community-based organizations
    • Regional organizations
    • Non-domestic (foreign) institutions and components
    • U.S. territories and possessions
• Individuals: Must be PI/PD of an active eligible NIH award; supplements must be within the competitive segment of the parent award.

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Application Process

• Step 1: Confirm eligibility and that your project aligns with an active Urgent Notice of Special Interest (NOSI) from an NIH IC.
• Step 2: Prepare a revision application using the SF424 (R&R) forms, following both the NIH Application Guide and any program-specific instructions in the FOA and NOSI.
• Step 3: Submit electronically via:
  • NIH ASSIST
  • Institutional system-to-system solution
  • Grants.gov Workspace
• Step 4: Ensure all required registrations (SAM, eRA Commons, Grants.gov) are current.
• Step 5: Only include supplemental activities in the application; do not duplicate parent award content.
• Step 6: Applications are routed to the NIH awarding component listed on the Notice of Award (NoA) of the parent grant.

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Additional Information

• Clinical Trials: Applications may propose or not propose clinical trials.
• Review Criteria: Emphasis on the appropriateness of the proposed expansion, responsiveness to the urgent public health need, and scientific merit.
• Reporting: Progress and budget for the supplement must be included in the parent award’s progress report, clearly delineated.
• Data Management: Supplements are subject to the same data management and sharing requirements as the parent award.
• Multiple Applications: Organizations may submit more than one application if each is scientifically distinct.

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External Links

• Full Funding Opportunity Announcement (FOA) – NIH
• Grants.gov Opportunity Listing
• NIH Notices of Special Interest (NOSI)
• NIH Application Guide (SF424 R&R)
• NIH eRA Commons
• NIH Grants Policy Statement

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Contact Information

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