[Alex's Lemonade Stand Foundation](https://www.alexslemonade.org)

April 2026 (Full application deadline, projected)

Up to $250,000 total direct costs over 2 years; max $125,000/year; no indirect costs allowed.

Funds late-translational, pre-clinical childhood cancer research to advance projects toward clinical trials within 2–3 years.

--- ## Description This grant supports pre-clinical, hypothesis-driven research projects in childhood cancer that are critical for translating innovative ideas into clinical applications. The primary aim is to help move promising research toward phase I and/or II clinical trials within two to three years after project completion. Projects should be milestone-driven and feasible, with strong preliminary data and a clear clinical trial development plan. The program encourages collaborative proposals and resource sharing to maximize research impact. --- ## Due Dates - April 2026 (anticipated full application deadline) *All dates are projected based on the annual cycle; check the program page for updates.* --- ## Funding Amount - Maximum of $250,000 in total direct costs over 2 years - Up to $125,000 per year - No indirect costs permitted - Clinical trial expenses are not eligible for funding - Follows NIH salary cap for investigators --- ## Eligibility - Applicant institutions must be nonprofit organizations based in the United States or Canada. - Applicants must have an MD, PhD, MD/PhD, or equivalent degree and hold a faculty (or equivalent) appointment at an academic institution. - Applicants must have a demonstrated track record in pediatric cancer research and translational research experience. - U.S. citizenship is not required. - Collaborative, multi-investigator proposals are encouraged. - Proposals must focus on childhood cancers (primary focus on patients ≤19 years old). - Projects must be late-translational; discovery, screening, or early translational projects are not eligible. --- ## Application Process - Applications must be submitted as a single PDF (max 20 MB) via [Proposal Central](https://proposalcentral.com). - ORCID registration is required for all applicants. - Required components include: cover page, table of contents, scientific abstract, impact statement, budget and justification, biographical sketches, research plan (including milestones and clinical trial plan), resource sharing plan, literature cited, human subjects and animal use documentation, and letters of support. - Only one resubmission is allowed for previously reviewed applications. - Annual progress reports and a final report are required. --- ## Additional Information - No indirect costs are allowed. - No clinical trial costs may be included. - Research using human embryonic/fetal stem cells or non-human primates is not eligible. - Resource and data sharing is expected; a detailed resource sharing plan is required. - Minor annual carry-over (≤25%) is permitted with justification. - One no-cost extension may be requested at project end. --- ## External Links - [Program Guidelines (PDF)](https://www.alexslemonade.org/sites/default/files/images/alsf1/downloads/2025_reach_grant_application_guidelines.pdf) - [Alex's Lemonade Stand Foundation Home](https://www.alexslemonade.org) - [Contact ALSF](https://www.alexslemonade.org/about/contact-us-now) --- ## Contact Information | Name/Role | Email | Phone | |------------------------|-------------------------------------------------|---------------| | Katy Estes-Smargiassi, Grant Coordinator | [K.ESmargiassi@alexslemonade.org](mailto:K.ESmargiassi@alexslemonade.org) | 610.649.3034 | | General Grants Contact | [Grants@AlexsLemonade.org](mailto:Grants@AlexsLemonade.org) | |

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