Description

This grant from the European Commission under Horizon Europe supports research and innovation actions focused on advancing tissue-specific, functional 3D bio-printing of living human cells for regenerative medicine. The aim is to overcome bottlenecks in translating bio-printed constructs to clinical settings, improve both in-vitro and in-situ bio-printing techniques, and enable clinical validation for repairing or regenerating complex tissues or internal organs. Projects should address engineering of bio-printing equipment for high cell-density constructs, scaling up to Good Manufacturing Practices (GMP)-compliant processes, and regulatory work necessary for clinical studies.

Proposals must be multidisciplinary, involving collaboration among engineers, biomedical scientists, cell biologists, and medical doctors. Consideration of regulatory frameworks, safety, quality requirements, and sex differences at the cellular level is required. Innovation integrating advanced imaging, surgical procedures, and real-time stimuli in the bio-printing process is encouraged.