Cellular Senescence Network (SenNet): SenNet Data Coordination, Integration and Organizational Center (U24 or UM1)
This grant will fund a center to coordinate, integrate, and organize data for mapping and analyzing senescent cells in human tissues to advance research on aging and age-related diseases.
Funder: National Institutes of Health
Due Dates: November 23, 2026 (Application deadline)
Funding Amounts: 25 expected cooperative agreement awards; no cost sharing or matching required
Summary: Supports SenNet Discovery and Validation Centers to validate cellular senescence signatures and biomarkers and investigate their consequences in human health and disease.
Key Information: Clinical trials are not allowed; applications should include consortium-wide organizational and outreach goals.
Description
The NIH Common Fund Cellular Senescence Network (SenNet) supports Discovery and Validation Centers as a core component of its Stage 2 activities. Building on Stage 1 resources, centers will define, refine, and validate tissue- and disease-relevant cellular senescence signatures, known as “senotypes,” and associated biomarkers. The program also supports investigation of their functional consequences in human health and disease.
Centers are expected to generate and contribute high-quality molecular, cellular, and spatial datasets, including relevant metadata and documentation. As appropriate, they will use complementary experimental systems to validate senotypes and biomarkers and characterize responses to senescence-associated perturbations or senotherapeutic approaches. Applications should also propose goals and aims for SenNet consortium-wide organizational and outreach activities, termed SenNet OOC functions.
