[Breakthrough T1D](https://www.breakthrought1d.org)

January 8, 2026 (Full proposal deadline)

Typical awards up to $3,000,000 total for up to 3 years; actual budget varies by project scope.

Supports research on shared mechanisms between type 1 diabetes and other autoimmune diseases to advance prevention or treatment strategies for T1D.

--- ## Description This program funds research investigating common pathways, processes, or molecular targets involved in both type 1 diabetes (T1D) and other autoimmune diseases. The goal is to generate new insights into autoimmunity that can inform prevention or treatment of T1D, leveraging knowledge from cross-disease comparisons and understanding of immune mechanisms shared among autoimmune conditions. --- ## Due Dates - January 8, 2026: Full proposal deadline (Common Mechanisms in Autoimmunity Insight Awards) --- ## Funding Amount - Awards typically provide up to $3,000,000 total for a project period of up to 3 years. - The actual funding amount and duration may vary depending on the scope and objectives of the proposed research. - Indirect costs are capped at 10% of direct costs for nonprofit applicants; for-profit (industry) applicants must provide matching funds and are not eligible for indirect costs. --- ## Eligibility - **Institutions:** Domestic and foreign nonprofit organizations, public and private universities, colleges, hospitals, laboratories, units of state and local governments, and eligible federal agencies. - **Applicants:** Must hold an M.D., D.O., D.M.D., D.V.M., Ph.D., or equivalent, and have a faculty position or equivalent at a research institution. - **Industry Applicants:** For-profit entities may apply under the Industry Discovery & Development Partnership (IDDP) mechanism, which requires company matching funds and additional requirements (see Grant Handbook for details). - Breakthrough T1D encourages applications from a diverse range of investigators and institutions. --- ## Application Process 1. **Letter of Intent (LOI):** Submission of an LOI is required before a full proposal can be submitted. Use the template provided on the [RMS360 portal](https://breakthrought1d.smartsimple.us/). 2. **Full Proposal:** Upon LOI approval, applicants will be invited to submit a full proposal via the RMS360 platform by the deadline. 3. **Platform:** All application materials must be submitted through [RMS360](https://breakthrought1d.smartsimple.us/). 4. **Templates and Guidelines:** Download and use the required templates from the portal. Follow the [Grant Handbook](https://www.breakthrought1d.org/granthandbook/) for detailed instructions on formatting, budget, and required attachments. 5. **Review:** Applications are evaluated for significance, relevance, innovation, approach, environment, and alignment with Breakthrough T1D’s mission. Additional review criteria may be detailed in the specific RFA. --- ## Additional Information - Projects must be relevant to T1D and focus on mechanisms common to T1D and other autoimmune diseases. - Human subjects or animal research must comply with relevant ethical and regulatory standards. - For industry applicants, contact Breakthrough T1D staff before submitting an LOI to discuss eligibility and matching requirements. - For questions about scientific fit or application procedures, refer to the RFA or Grant Handbook for designated contacts. --- ## External Links - [Program Page & Funding Opportunities](https://www.breakthrought1d.org/explore-research/funding-opportunities/#psychosocial-fellowships-not-offered-details-below) - [Grant Handbook](https://www.breakthrought1d.org/granthandbook/) - [Application Portal (RMS360)](https://breakthrought1d.smartsimple.us/) - [Common Mechanisms Insight Awards RFA (PDF)](https://www.breakthrought1d.org/wp-content/uploads/2025/11/CommonMechanismsCallDocRFAFY26.pdf) - [Privacy Policy](https://www.breakthrought1d.org/privacy/) --- ## Contact Information | Purpose | Contact Person | Email | |--------------------------|--------------------------|-----------------------------------------| | Strategic/Scientific Qs | See RFA for details | [Contact Breakthrough T1D](https://www.breakthrought1d.org/contact-us/) | | General Administration | See Grant Handbook | [Contact Breakthrough T1D](https://www.breakthrought1d.org/contact-us/) | For specific program officer contacts, consult the RFA or reach out via the contact form above.

Common Mechanisms in Autoimmunity Insight Awards

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