Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)
NIH funds centers to develop and test predictive models and integrative analyses of how genomic variation affects genome function, working within a collaborative consortium.
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Funder: National Institutes of Health
Due Dates: November 14, 2026 (Earliest submission) | December 14, 2026 (Application deadline)
Funding Amounts: Up to $800,000 in direct costs; maximum project period of 5 years; $5 million total program funding
Summary: Supports computational modeling and integrative analysis centers predicting how genomic variation affects genome function and phenotype within the IGVF Consortium.
Key Information: Centers must participate in consortium-wide collaboration and open resource sharing; clinical trials and foreign subawards/subcontracts are not allowed.
Description
The National Human Genome Research Institute (NHGRI), part of NIH, supports modeling and analysis centers through this UM1 cooperative agreement for the second phase of the Impact of Genomic Variation on Function (IGVF) Consortium. Centers will develop, apply, and test predictive models and perform integrative analyses to understand how genomic variation affects genome function and phenotype. Models must predict impacts in human or mouse genomes and leverage existing and newly generated IGVF data.
Supported work includes predicting untested variant effects, context-specific effects, variant–variant or variant–environment interactions, network-level effects, causal variants, and variants most informative for experimental testing. Centers will also guide experimental design, lead consortium-wide analyses, and share predictions through the IGVF catalog and data portal. The program emphasizes generalizable, interpretable models and resources useful beyond the consortium.
