[Cancer Research Institute](https://www.cancerresearch.org)

November 15, 2025 (Letter of Intent) | March 13, 2026 (Full Proposal)

Up to $600,000 over 2–4 years; 10% indirect costs provided in addition to award.

Supports early-stage, high-risk technology innovations with transformative potential in cancer immunotherapy.

Two-step application: LOI required; international and US-based nonprofit institutions eligible.

--- ## Description The CRI Technology Impact Award provides seed funding for early-stage, pre-development concepts that could fundamentally transform cancer immunotherapy. The program is designed to bridge the gap between conceptual technological innovation and clinical application, encouraging collaborations between technology developers and clinical cancer immunologists. The award specifically targets visionary, high-risk/high-reward ideas, rather than incremental improvements to existing technologies. Supported innovations may include computational systems biology, advanced profiling, real-time visualization, complex multicellular culture systems, and novel therapeutic technologies. Proposals are assessed for novelty, creativity, technical sophistication, and transformative potential to accelerate the discovery of disruptive, next-generation immunotherapies. --- ## Due Dates - November 15, 2025: Letter of Intent deadline - March 13, 2026: Invited full application (full proposal) deadline Applicants will be notified by mid-February 2026 if invited to submit a full application. If deadlines fall on a weekend, submissions are accepted the following Monday. Applications are due by 11:59 p.m. Eastern Time on each date. The earliest an award can activate is July 1, and awards activate on the first of the month. --- ## Funding Amount - Up to $600,000 total funding over 2–4 years per award. - 10% indirect costs provided in addition to the awarded funds. - Funding is intended as seed support for entirely new technologies; not for incremental improvements or the extension of existing technologies. --- ## Eligibility - Applicants must hold a tenure-track position at a nonprofit research institution (US or international). - No citizenship restrictions; research can be conducted in the US or abroad. - Clinical cancer immunologists and technology developers are encouraged to collaborate. - Co-Principal Investigators (Co-PIs) are eligible and encouraged. - Proposals must be project-specific and non-overlapping with other CRI programs. - Applications from the same institution are allowed if scientifically distinct. --- ## Application Process ### Two-Step Submission 1. **Letter of Intent (LOI)** - Submit electronically via the [CRI Grants Portal](https://cri.us-1.smartsimple.com/s_Login.jsp). - LOI should succinctly describe the research plan, specific aims, timeline, and transformative potential (max 3 pages). 2. **Invited Full Proposal** - Only applicants invited after LOI review may submit a full proposal. - Required materials (all as individual PDFs): - Initial research concept (max 3 pages) - Brief description of current research - Curriculum vitae (NIH biosketch accepted/preferred) - Bibliography (past 5 years or relevant publications) - CVs and roles for all group members, if applicable - All documents must be formatted single-spaced with a minimum 12-point font. - Incomplete or over-length applications will be disqualified. - Submit all materials online before the stated deadlines. --- ## Additional Information - The award does **not** support clinical trials, but samples from independently funded trials may be used for technology development. - Indirect costs (up to 10%) are provided in addition to the award. - Award activation must occur within one year of the full proposal deadline. - Annual invention disclosure and revenue-sharing agreements are required for inventions arising from funded research. - CRI implements a salary cap consistent with NIH guidelines. - Resubmissions are allowed if revised and updated. --- ## External Links - [Program Page & Application Instructions](https://www.cancerresearch.org/technology-impact-award) - [CRI Grants Portal (Application Submission)](https://cri.us-1.smartsimple.com/s_Login.jsp) - [Frequently Asked Questions](https://www.cancerresearch.org/programs-faqs) - [Invention Disclosure Form (PDF)](https://www.cancerresearch.org/wp-content/uploads/2025/08/CRI-Invention-Disclosure-Form-1-2025.pdf) - [Annual Invention Update Form (PDF)](https://www.cancerresearch.org/wp-content/uploads/2025/08/Annual-Invention-Update-Form-1-2025.pdf) - [Standard Revenue Sharing Agreement (PDF)](https://www.cancerresearch.org/wp-content/uploads/2022/10/Revenue-Sharing-Agreement.pdf) - [View Past Awardees](https://www.cancerresearch.org/cri-funded-scientists?grant=tech-impact-award) --- ## Contact Information | Purpose | Contact Details | |------------------------|-----------------------------------------------------------| | General Inquiries | [grants@cancerresearch.org](mailto:grants@cancerresearch.org) | | Phone | (800) 992-2623 | | Funder Contact Page | [Contact CRI](https://www.cancerresearch.org/contact) | | Mailing Address | Cancer Research Institute, 29 Broadway, Floor 4, New York, NY 10006-3111, USA | ---

CRI Technology Impact Award

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