Development of cell-free protein synthesis platforms for discovery and/or production of biologicals - European Commission
Funds research to develop advanced cell-free protein synthesis platforms for efficient, scalable production of biological therapeutics and vaccines in the EU health sector.
Funder: European Commission
Due Dates: April 13, 2027 (Submission deadline, full proposal)
Funding Amounts: €6,000,000–€8,000,000 per project | 4 grants anticipated
Summary: Funds R&D to advance cell-free protein synthesis platforms for efficient and scalable production of biological therapeutics and vaccines in the EU health sector.
Key Information: Legal entities established in China are not eligible; single-stage application process.
Description
This grant supports research and innovation actions aimed at developing advanced cell-free protein synthesis (CFPS) platforms for the discovery and/or production of peptide- or protein-based biologicals. The program seeks to overcome current bottlenecks in large-scale CFPS deployment, such as quality-by-design, characterization of cell lysates, and understanding process parameters impacting product quality.
Projects are encouraged to use synthetic biology and generative AI for designing new biomolecules, and to develop or optimize CFPS platforms that can comply with Good Manufacturing Practices (GMP) for clinical-grade material. The initiative aims to leverage the efficiency, flexibility, and scalability of CFPS to enable rapid and decentralized manufacturing, facilitate standardization, and support personalized medicine. Anticipated impacts include transforming the production of therapeutics and vaccines for both communicable and non-communicable diseases, and enhancing the innovation, sustainability, and competitiveness of the EU health industry.
