Expression of interest: Precision prevention: biological mechanisms of response variation
UK Research and Innovation funds research to uncover biological mechanisms behind individual variation in response to prevention interventions, advancing precision prevention in human health.
Funder: UK Research and Innovation
Due Dates: September 17, 2026 (EOI deadline) | November 5, 2026 (Full application, by invitation)
Funding Amounts: Up to £5 million FEC per project (MRC funds 80% FEC); total call budget £15 million; project duration: 3–5 years.
Summary: Supports experimental research in humans to uncover biological mechanisms underlying individual variation in response to biomedical prevention interventions, advancing precision prevention strategies.
Key Information: Submission of an Expression of Interest (EOI) by September 17, 2026, is mandatory for full application eligibility.
Description
This opportunity, provided by the Medical Research Council (MRC) through UK Research and Innovation (UKRI), funds research projects that investigate the biological mechanisms driving variation in individual and population-level responses to biomedical prevention interventions. The scheme specifically supports experimental medicine studies in humans, focusing on mechanistic hypotheses and the use of biomedical interventions or challenges in pre-disease or early disease states. The goal is to generate mechanistic evidence that can inform the targeting, timing, and delivery of more effective, equitable, and personalized prevention strategies, ultimately supporting improved health outcomes and reducing health inequalities.
